EP 1420635 A1 20040526 - DEVELOPMENT OF TRANSGENIC MODEL FOR INTERVENTIONS IN NEURODEGENERATIVE DISEASES
Title (en)
DEVELOPMENT OF TRANSGENIC MODEL FOR INTERVENTIONS IN NEURODEGENERATIVE DISEASES
Title (de)
TRANSGENES MODELL ZUR BEHANDLUNG VON NEURODEGENERATIVEN ERKRANKUNGEN
Title (fr)
DEVELOPPEMENT D'UN MODELE TRANSGENIQUE INTERVENANT DANS DES MALADIES NEURODEGENERATIVE
Publication
Application
Priority
US 0126095 W 20010820
Abstract (en)
[origin: WO03015507A1] Alzheimer's disease, Parkinson's disease and Lewy body disease are the most commonly found neurodegenerative disorders in the elderly. The invention is a transgenic mouse that contains two transgenes, human alpha -synuclein and human amyloid precursor protein, which are responsible for the formation of the neuritic plaques, Lewy bodies and neurodegeneration seen in the above mentioned diseases. The transgenic mouse is an accurate model for disease by both functional and pathological assays.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); A61K 49/00 (2006.01); C07K 14/47 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP)
A01K 67/0275 (2013.01); A01K 67/0278 (2013.01); A61K 49/0008 (2013.01); C07K 14/47 (2013.01); C07K 14/4711 (2013.01); C12N 15/8509 (2013.01); A01K 2207/15 (2013.01); A01K 2217/00 (2013.01); A01K 2217/05 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0312 (2013.01); A01K 2267/0318 (2013.01); C12N 2830/008 (2013.01)
Citation (search report)
See references of WO 03015507A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 03015507 A1 20030227; CA 2458193 A1 20030227; EP 1420635 A1 20040526; JP 2004538013 A 20041224
DOCDB simple family (application)
US 0126095 W 20010820; CA 2458193 A 20010820; EP 01964267 A 20010820; JP 2003520278 A 20010820