EP 1420815 A2 20040526 - BETA-AMYLOID-ANALOGUE - T-CELL EPITOP VACCINE
Title (en)
BETA-AMYLOID-ANALOGUE - T-CELL EPITOP VACCINE
Title (de)
BETA-AMYLOID-ANALOG - T-ZELL EPITOP IMPFSTOFF
Title (fr)
VACCIN A BASE D'UN ANALOGUE DE LA BETA-AMYLOIDE ET D'UN EPTITOPE T
Publication
Application
Priority
- DK 0200547 W 20020820
- DK PA200101231 A 20010820
- DK PA200200558 A 20020416
- US 33754301 P 20011022
- US 37302702 P 20020416
Abstract (en)
[origin: WO03015812A2] Disclosed are novel methods for combatting diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protein (APP) or beta amyloid (A beta ). Immunization is preferably effected by administration of analogues of autologous APP or A beta , said analogues being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous A beta which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Also disclosed are nucleic acid vaccination against APP or A beta and vaccination using live vaccines as well as methods and means useful for the vaccination. Such methods and means include methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 35/74 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 39/02 (2006.01); A61K 39/10 (2006.01); A61K 39/12 (2006.01); A61K 39/385 (2006.01); A61K 39/39 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61K 48/00 (2006.01); A61P 3/10 (2006.01); A61P 25/00 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); C07K 14/47 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01)
IPC 8 main group level
CPC (source: EP KR US)
A01K 67/0275 (2013.01 - EP US); A61K 39/0007 (2013.01 - EP US); A61K 39/385 (2013.01 - EP KR US); A61K 45/06 (2013.01 - EP US); A61P 3/10 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/14 (2018.01 - EP); A61P 25/16 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 37/04 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07K 14/4711 (2013.01 - EP US); A01K 2217/05 (2013.01 - EP US); A01K 2227/105 (2013.01 - EP US); A01K 2267/0312 (2013.01 - EP US); A61K 2039/53 (2013.01 - EP US); A61K 2039/6037 (2013.01 - EP US); A61K 2039/6068 (2013.01 - EP US); A61K 2039/6087 (2013.01 - EP US); A61K 2039/6093 (2013.01 - EP US); A61K 2039/64 (2013.01 - EP US); Y02A 50/30 (2018.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03015812 A2 20030227; WO 03015812 A3 20040325; AR 036270 A1 20040825; AT E334698 T1 20060815; AU 2002325199 B2 20070920; AU 2007249087 A1 20080110; AU 2007249087 B2 20100520; AU 2010212381 A1 20100909; AU 2010212381 B2 20120119; BR 0212047 A 20040817; CA 2457140 A1 20040227; CA 2457140 C 20140805; CN 101675992 A 20100324; CN 101675992 B 20140521; CO 5560581 A2 20050930; CY 1105737 T1 20101222; DE 60213615 D1 20060914; DE 60213615 T2 20070809; DE 60213615 T3 20171123; DK 1420815 T3 20061204; EA 007533 B1 20061027; EA 011610 B1 20090428; EA 200400332 A1 20040826; EA 200600974 A1 20061027; EP 1420815 A2 20040526; EP 1420815 B1 20060802; EP 1420815 B2 20170809; EP 1685847 A1 20060802; EP 3299029 A1 20180328; ES 2269749 T3 20070401; ES 2269749 T5 20171204; HK 1064934 A1 20050208; HR P20040218 A2 20040831; HR P20120283 A2 20120630; HU P0400669 A2 20050128; HU P0400669 A3 20110728; IL 159964 A0 20040620; IL 188506 A0 20080413; IL 188506 A 20170831; IS 7133 A 20040129; JP 2004538332 A 20041224; JP 2009280582 A 20091203; JP 5114455 B2 20130109; KR 101057488 B1 20110819; KR 20040044465 A 20040528; KR 20090074830 A 20090707; KR 20100086520 A 20100730; ME P43208 A 20110210; MX PA04001467 A 20050217; MY 144532 A 20110930; NZ 530940 A 20071130; NZ 547224 A 20080630; PL 215125 B1 20131031; PL 369099 A1 20050418; PT 1420815 E 20061229; RS 51699 B 20111031; SI 1420815 T1 20061231; US 2003157117 A1 20030821; US 2005163744 A1 20050728; US 2010047262 A1 20100225; US 8871212 B2 20141028; YU 13304 A 20060817
DOCDB simple family (application)
DK 0200547 W 20020820; AR P020103113 A 20020820; AT 02758181 T 20020820; AU 2002325199 A 20020820; AU 2007249087 A 20071218; AU 2010212381 A 20100816; BR 0212047 A 20020820; CA 2457140 A 20020820; CN 200910204496 A 20020820; CO 04015504 A 20040223; CY 061101544 T 20061026; DE 60213615 T 20020820; DK 02758181 T 20020820; EA 200400332 A 20020820; EA 200600974 A 20020820; EP 02758181 A 20020820; EP 06000288 A 20020820; EP 17194894 A 20020820; ES 02758181 T 20020820; HK 04107588 A 20041004; HR P20040218 A 20040305; HR P20120283 A 20120330; HU P0400669 A 20020820; IL 15996402 A 20020820; IL 18850607 A 20071231; IS 7133 A 20040129; JP 2003520770 A 20020820; JP 2009141187 A 20090612; KR 20047002557 A 20020820; KR 20097013183 A 20020820; KR 20107015762 A 20020820; ME P43208 A 20020820; MX PA04001467 A 20020820; MY PI20023002 A 20020813; NZ 53094002 A 20020820; NZ 54722402 A 20020820; PL 36909902 A 20020820; PT 02758181 T 20020820; SI 200230418 T 20020820; US 22380902 A 20020820; US 33984108 A 20081219; US 78331704 A 20040220; YU P13304 A 20020820