EP 1420823 A2 20040526 - IMMUNOGENIC COMPOSITIONS CONTAINING ANTIGENS, GENE VECTORS AND ADJUVANTS-LOADED BIODEGRADABLE MICROSPHERES
Title (en)
IMMUNOGENIC COMPOSITIONS CONTAINING ANTIGENS, GENE VECTORS AND ADJUVANTS-LOADED BIODEGRADABLE MICROSPHERES
Title (de)
IMMUNOGENE ZUSAMMENSETZUNGEN MIT ANTIGENEN, GENVEKTOREN UND MIT ADJUVANTIEN BELADENEN BIOLOGISCH ABBAUBAREN MIKROKÜGELCHEN
Title (fr)
COMPOSITIONS IMMUNOGENES CONTENANT DES ANTIGENES, DES VECTEURS GENIQUES ET DES MICROSPHERES BIODEGRADABLES CHARGEES D'ADJUVANTS
Publication
Application
Priority
- BR 0200099 W 20020717
- BR 0103887 A 20010717
Abstract (en)
[origin: WO03007869A2] The present invention relates to compositions which are able to stimulate an immune response in a host inoculated with an antigen of interest or the gene vector that codifies it. This composition includes microspheres based on copolymers derived from lactic acid glycolic acid encapsulating antigens, gene vectors and/or adjuvants with immunostimulatory properties obtained from mycobacterial fractions. The materialization of the present invention is the use of trehalose dimycolate associated to a heat shock protein or to the plasmid containing the gene that codifies it, encapsulated in microspheres with size smaller than 10 mu m, capable of inducing specific antobodies and cellular immune responses, as well as the secretion of cytokines implicated in the protection against infectious diseases and cancer, following administration of a single dose or several doses.
IPC 1-7
IPC 8 full level
A61K 9/16 (2006.01); A61K 39/04 (2006.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01); C12N 5/22 (2006.01); A61K 9/00 (2006.01)
CPC (source: EP)
A61K 9/1647 (2013.01); A61K 39/04 (2013.01); A61P 31/00 (2017.12); A61P 31/06 (2017.12); A61P 35/00 (2017.12); A61P 37/04 (2017.12); A61K 2039/55583 (2013.01); A61K 2039/55594 (2013.01)
Citation (search report)
See references of WO 03007869A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03007869 A2 20030130; WO 03007869 A3 20040318; BR 0103887 A 20030805; BR 0103887 C1 20051108; CA 2453959 A1 20030130; CN 1549728 A 20041124; EP 1420823 A2 20040526
DOCDB simple family (application)
BR 0200099 W 20020717; BR 0103887 A 20010717; CA 2453959 A 20020717; CN 02817186 A 20020717; EP 02744957 A 20020717