EP 1421059 A1 20040526 - PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED N-ACYL-BETA-AMINO ACID DERIVATIVES BY ENANTIOSELECTIVE HYDROGENATION OF THE CORRESPONDING (Z)-ENAMIDES
Title (en)
PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED N-ACYL-BETA-AMINO ACID DERIVATIVES BY ENANTIOSELECTIVE HYDROGENATION OF THE CORRESPONDING (Z)-ENAMIDES
Title (de)
PROZESS ZUR HERSTELLUNG VON ENANTIOMERENANGEREICHERTEN N-ACYL-BETA AMINOSÄURE DERIVATEN DURCH ENANTIOSELEKTIVE HYDROGENIERUNG DER KORRESPONDIERENDEN (Z)-ENAMIDE
Title (fr)
PROCEDE DE PREPARATION DE DERIVES DE N-ACYL-BETA-AMINO ACIDES ENRICHIS EN ENANTIOMERES PAR HYDROGENATION ENANTIOSELECTIVE DE (Z)-ENAMIDES CORRESPONDANTS
Publication
Application
Priority
- GB 0120167 A 20010817
- US 0226142 W 20020816
Abstract (en)
[origin: WO03016264A1] A process for the preparation of an enantiomerically enriched beta-amino acid derivative of formula (1), or the opposite enantiomer thereof, wherein R1 is an optionally substituted alkyl, aryl or heteroaryl group of up to 20 C atoms, R2 is ann alkyl group of up to 20 C atoms, and R3 is H or an alkyl or aryl group of up to 20 C atoms, which comprises asymmetric hydrogenation of the (z)-enamide precursor (2) in an alcohol solvent or cosolvent, catalysed by a cationic rhodium complex of a chiral phosphine ligand having the partial formula (3), wherein n is 0 to 6 and R represents at least one non-hydrogen organic group of up to 20 C atoms.
IPC 1-7
IPC 8 full level
C07B 61/00 (2006.01); C07C 231/12 (2006.01); C07C 231/18 (2006.01); C07C 233/47 (2006.01); C07C 233/51 (2006.01); C07C 233/83 (2006.01)
CPC (source: EP)
C07C 231/12 (2013.01); C07C 231/18 (2013.01); C07C 233/47 (2013.01); C07C 233/51 (2013.01); C07B 2200/07 (2013.01)
Citation (search report)
See references of WO 03016264A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03016264 A1 20030227; EP 1421059 A1 20040526; GB 0120167 D0 20011010; JP 2005518339 A 20050623
DOCDB simple family (application)
US 0226142 W 20020816; EP 02757176 A 20020816; GB 0120167 A 20010817; JP 2003521193 A 20020816