EP 1421101 A4 20050119 - P-GLYCOPROTEINS AND USES THEREOF
Title (en)
P-GLYCOPROTEINS AND USES THEREOF
Title (de)
P-GLYCOPROTEINE UND DEREN VERWENDUNGEN
Title (fr)
GLYCOPROTEINES P ET LEURS UTILISATIONS
Publication
Application
Priority
- US 0208325 W 20020319
- US 27709501 P 20010319
Abstract (en)
[origin: WO02074048A2] The invention pertains to rhesus monkey P-glycoproteins and related P-gylcoproteins which include rhesus-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the rhesus monkey P-gylcoprotein. The invention further relates to methods of using such rhesus monkey P-glycoprotein nucleic acids and polypeptides, especially in methods for determining bioavailability of drugs and for screening for inhibitors of rhesus PGP. Also included are rhesus PGP inhibitors which inhibit rhesus PGP activity by inhibiting the expression or function of rhesus PGP.
IPC 1-7
C07K 1/00; C07K 4/00; C07K 17/00; C12N 15/00; C12N 15/09; C12N 15/63; C12N 15/70; C12N 15/74; C12P 21/06
IPC 8 full level
A61K 31/711 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); C12Q 1/42 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP US)
A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/705 (2013.01 - EP US)
Citation (search report)
- [PX] WO 0123540 A2 20010405 - GENTEST CORP [US]
- [A] WO 9740160 A1 19971030 - UNIV GRONINGEN [NL], et al
- [A] WO 9510603 A1 19950420 - NOVO NORDISK AS [DK], et al
- [A] LEHMANN M ET AL: "The consensus concept for thermostability engineering of proteins", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1543, no. 2, 29 December 2000 (2000-12-29), pages 408 - 415, XP004279115, ISSN: 0006-3002
- See references of WO 02074048A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02074048 A2 20020926; WO 02074048 A3 20040325; WO 02074048 A8 20030828; AU 2002367884 A1 20021003; EP 1421101 A2 20040526; EP 1421101 A4 20050119; JP 2005503764 A 20050210; US 2003119726 A1 20030626; US 6855812 B2 20050215
DOCDB simple family (application)
US 0208325 W 20020319; AU 2002367884 A 20020319; EP 02728505 A 20020319; JP 2002572775 A 20020319; US 10143302 A 20020319