EP 1421118 A1 20040526 - A METHOD FOR THE TREATMENT OR PREVENTION OF BONE EROSION
Title (en)
A METHOD FOR THE TREATMENT OR PREVENTION OF BONE EROSION
Title (de)
METHODE ZUR BEHANDLUNG UND VERHINDERUNG DES KNOCHENABBAUS
Title (fr)
TECHNIQUE DE TRAITEMENT OU DE PREVENTION DE L'EROSION OSSEUSE
Publication
Application
Priority
- JP 0208630 W 20020827
- JP 2001257436 A 20010828
Abstract (en)
[origin: WO03020768A1] There is provided a method for the treatment or prevention of bone erosion caused by a disease that activates osteoclasts (e.g. rheumatoid arthritis) comprising administering to a patient an anti-human Fas monoclonal antibody HFE7A or a humanized version thereof, as well as a composition for use in such a method. There is also provided a method for testing a substance for the treatment or prevention of bone erosion comprising: transplanting pieces of dentine and synovial tissue from a patient suffering from a disease that activates osteoclasts to immunodeficient non-human mammals; administering the substance to be tested to at least one of the test animals and a control to at least one different test animal and breeding them; and then extracting said pieces of dentine from the test animals and counting the number of resorption pits formed on the surface of each piece that was in contact with said sample of synovial tissue.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61P 19/02 (2006.01); A61P 19/10 (2006.01); C07K 16/28 (2006.01)
CPC (source: EP)
A61K 31/00 (2013.01); A61K 39/39541 (2013.01); A61K 45/06 (2013.01); A61P 19/02 (2017.12); A61P 19/10 (2017.12); C07K 16/2878 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01)
Citation (search report)
See references of WO 03020768A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03020768 A1 20030313; AR 036305 A1 20040825; CA 2458993 A1 20030313; EP 1421118 A1 20040526; PA 8553901 A1 20030630; PE 20030340 A1 20030405
DOCDB simple family (application)
JP 0208630 W 20020827; AR P020103216 A 20020827; CA 2458993 A 20020827; EP 02762875 A 20020827; PA 8553901 A 20020828; PE 2002000815 A 20020826