Global Patent Index - EP 1423081 A4

EP 1423081 A4 2005-05-25 - COMPOSITION COMPRISING GLYCOSAMINOGYCANS AND HYALURONIDASE INHIBITORS FOR THE TREATMENT OF ARTHRITIC JOINTS

Title (en)

COMPOSITION COMPRISING GLYCOSAMINOGYCANS AND HYALURONIDASE INHIBITORS FOR THE TREATMENT OF ARTHRITIC JOINTS

Title (de)

ZUSAMMENSETZUNG MIT GLYCOSAMINOGYCANEN UND HYALURONIDASE-HEMMERN ZUR BEHANDLUNG ARTHRITISCHER GELENKE

Title (fr)

COMPOSITION COMPRENANT DES GLYCOSAMINOGLYCANES ET DES INHIBITEURS D'HYALURONIDASE DESTINEE AU TRAITEMENT D'ARTICULATIONS ARTHRITIQUES

Publication

EP 1423081 A4 (EN)

Application

EP 02739947 A

Priority

  • US 0219718 W
  • US 30073401 P
  • US 74102 A

Abstract (en)

[origin: WO03000191A2] A preferred embodiment of the present invention is directed to a composition and method for treating arthritis comprising one or more glycosaminoglycans in combination with one or more hyaluronidase inhibitor. In a more preferred embodiment the present invention is directed to a composition and method for treating arthritis comprising one or more glycosaminoglycans which would include at least hyaluronic acid in combination with one or more hyaluronidase inhibitors selected from the group consisting of heparan sulphate, dextran sulphate and xylose sulphate. In still a more preferred embodiment the present invention relates to a composition and method for treating arthritis comprising hyaluronic acid co-encapsulated with a hyaluronidase inhibitor in liposomes. Hyaluronic acid in the composition would confer the viscosupplement properties to the joint. The function of the hyaluronidase inhibitor would be to act as a preservative, and protect the hyaluronic acid from premature degradation in the joint. The liposomal encapsulation and delivery of the composition would serve as a slow release depot for the hyaluronic acid and the hyaluronidase inhibitor. This invention therefore provides a means of delivering stable and long lasting high molecular weight HA to the joint. The therpeutic effectiveness of the liposome co-encapsulated hyaluronic acid with the hyaluronidase inhibitor would be greater than simple injection of hyaluronic acid. The preferred method of treatment would be by intra-articular injection of an admixture of hyaluronic acid and a hyaluronidase inhibitor, optionally encapsulated in liposomes. The treatment is more effective than currently available treatments based on HA alone.

IPC 1-7

A61K 31/715; A61K 9/127; A61K 31/352; A61K 31/4152; A61K 31/726; A61K 31/727; A61K 31/728; A61K 33/24; A61P 29/00

IPC 8 full level

A61K 9/127 (2006.01); A61K 31/352 (2006.01); A61K 31/353 (2006.01); A61K 31/4152 (2006.01); A61K 31/7004 (2006.01); A61K 31/7016 (2006.01); A61K 31/726 (2006.01); A61K 31/727 (2006.01); A61K 31/728 (2006.01); A61K 31/737 (2006.01); A61K 33/24 (2006.01); A61K 45/00 (2006.01); A61K 47/24 (2006.01); A61P 19/02 (2006.01); A61P 43/00 (2006.01)

CPC

A61K 31/7004 (2013.01); A61K 31/352 (2013.01); A61K 31/353 (2013.01); A61K 31/4152 (2013.01); A61K 31/7016 (2013.01); A61K 31/726 (2013.01); A61K 31/727 (2013.01); A61K 31/728 (2013.01); A61K 33/24 (2013.01)

C-Set

  1. A61K 31/352 + A61K 2300/00
  2. A61K 31/353 + A61K 2300/00
  3. A61K 31/4152 + A61K 2300/00
  4. A61K 31/7004 + A61K 2300/00
  5. A61K 31/7016 + A61K 2300/00
  6. A61K 31/726 + A61K 2300/00
  7. A61K 31/727 + A61K 2300/00
  8. A61K 31/728 + A61K 2300/00
  9. A61K 33/24 + A61K 2300/00

Citation (search report)

  • [X] WO 9012561 A1 19901101 - BUKH MEDITEC [DK]
  • [XD] WO 0074662 A2 20001214 - UNIV SHEFFIELD [GB], et al
  • [X] TORSTEINSDOTTIR I ET AL: "Production and elimination of hyaluronan in rheumatoid arthritis patients: estimation with a loading test", SEMINARS IN ARTHRITIS AND RHEUMATISM, XX, XX, vol. 28, no. 4, February 1999 (1999-02-01), pages 268 - 279, XP004680850, ISSN: 0049-0172
  • [A] KUPPUSAMY U R ET AL: "STRUCTURE-ACTIVITY STUDIES OF FLAVONOIDS AS INHIBITORS OF HYALURONIDASE", BIOCHEMICAL PHARMACOLOGY, vol. 40, no. 2, 1990, pages 397 - 401, XP002322723, ISSN: 0006-2952
  • See also references of WO 03000191A3

DCS

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family

WO 03000191 A2 20030103; WO 03000191 A3 20040311; CA 2451248 A1 20030103; EP 1423081 A2 20040602; EP 1423081 A4 20050525; JP 2005521629 A 20050721