EP 1425306 A2 20040609 - NANOPARTICLES COMPRISING BIOLOGICALLY ACTIVE TNF WHICH IS IMMOBILISED ON THE SAME
Title (en)
NANOPARTICLES COMPRISING BIOLOGICALLY ACTIVE TNF WHICH IS IMMOBILISED ON THE SAME
Title (de)
NANOPARTIKEL MIT DARAN IMMOBILISIERTEM BIOLOGISCH AKTIVEM TNF
Title (fr)
NANOPARTICULES COMPORTANT LE FACTEUR DE NECROSE DES TUMEURS TNF A ACTIVITE BIOLOGIQUE, IMMOBILISE DESSUS
Publication
Application
Priority
- DE 10144252 A 20010831
- EP 0209185 W 20020816
Abstract (en)
[origin: WO03020320A2] The invention relates to nanoparticles comprising tumour necrosis factor (TNF) or cytokine, immobilised thereon, the TNF or cytokine preferably being oriented in the form of a trimer and being immobilised on the carrier while maintaining its biological activity. The invention also relates to methods for the oriented immobilisation of TNF or cytokine on nanoparticles, to the use of nanoparticles comprising immobilised TNF or cytokine for the identification and/or isolation of cytokine or TNF binding partners, and for the identification and/or isolation of inhibitors of the interaction between TNF or cytokine and the binding partners thereof, to the use of such nanoparticles for producing a pharmaceutical composition, especially for the treatment of tumours, and to pharmaceutical and diagnostic compositions containing such nanoparticles.
IPC 1-7
IPC 8 full level
A61K 9/127 (2006.01); A61K 9/51 (2006.01); A61K 38/00 (2006.01); A61K 38/19 (2006.01); A61K 47/02 (2006.01); A61K 47/04 (2006.01); A61K 47/30 (2006.01); A61K 47/32 (2006.01); A61K 47/34 (2006.01); A61K 47/36 (2006.01); A61K 47/48 (2006.01); A61K 49/00 (2006.01); A61K 51/00 (2006.01); A61P 9/00 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); C07K 17/06 (2006.01)
CPC (source: EP US)
A61K 38/191 (2013.01 - EP US); A61K 47/62 (2017.07 - EP US); A61K 47/6923 (2017.07 - EP US); A61K 47/6933 (2017.07 - EP US); A61P 9/00 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); B82Y 5/00 (2013.01 - EP US); C07K 17/06 (2013.01 - EP US)
Citation (search report)
See references of WO 03020320A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03020320 A2 20030313; WO 03020320 A3 20031030; AU 2002333444 A1 20030318; CA 2458682 A1 20030313; DE 10144252 A1 20030327; EP 1425306 A2 20040609; JP 2005504066 A 20050210; US 2004265392 A1 20041230; US 7368295 B2 20080506
DOCDB simple family (application)
EP 0209185 W 20020816; AU 2002333444 A 20020816; CA 2458682 A 20020816; DE 10144252 A 20010831; EP 02797581 A 20020816; JP 2003524625 A 20020816; US 48837404 A 20040521