EP 1432725 A4 20050330 - RNA INTERFERENCE MEDIATED INHIBITION OF TELOMERASE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
Title (en)
RNA INTERFERENCE MEDIATED INHIBITION OF TELOMERASE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
Title (de)
RNA-INTERFERENZ-VERMITTELTE INHIBIERUNG VON TELOMERASEGENEXPRESSION MIT KURZER INTERFERIERENDER NUKLEINSÄURE (SINA)
Title (fr)
INHIBITION INDUITE PAR L'INTERFERENCE DE L'ARN DE L'EXPRESSION DU GENE TELOMERASE AU MOYEN D'UN ACIDE NUCLEIQUE A BREVE INTERFERENCE (SINA)
Publication
Application
Priority
- US 0304088 W 20030211
- US 35858002 P 20020220
- US 36312402 P 20020311
- US 38678202 P 20020606
- US 39660002 P 20020717
- US 40678402 P 20020829
- US 40837802 P 20020905
- US 40929302 P 20020909
- US 44012903 P 20030115
Abstract (en)
[origin: WO03070742A1] The present invention concerns methods and reagents useful in modulating telomerase gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small 5 nucleic acid molecules, such as short interfering nucleic acid siNA, short interfering RNA siRNA, double-stranded RNA dsRNA, micro-RNA miRNA, and short hairpin RNA shRNA molecules capable of mediating RNA interference RNAi against a telomerase protein TERT or telomerase template RNA TERC/TR. The small nucleic acid molecules are useful in the treatment of cancer.
IPC 1-7
C12Q 1/68; C12P 19/34; C12N 15/85; C12N 15/86; C07H 21/02; C07H 21/04; A61K 48/00
IPC 8 full level
A61K 47/48 (2006.01); C12N 15/113 (2010.01); C12N 15/115 (2010.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 47/54 (2017.07); C12N 15/1132 (2013.01); C12N 15/1137 (2013.01); C12N 15/115 (2013.01); C12Y 104/03003 (2013.01); C12Y 114/19001 (2013.01); C12Y 207/07049 (2013.01); C12Y 207/11001 (2013.01); C12Y 207/11013 (2013.01); C12Y 301/03048 (2013.01); A61K 38/00 (2013.01); C12N 2310/111 (2013.01); C12N 2310/12 (2013.01); C12N 2310/121 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/317 (2013.01); C12N 2310/318 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/332 (2013.01); C12N 2310/346 (2013.01); C12N 2310/53 (2013.01)
Citation (search report)
- [Y] WO 0174136 A2 20011011 - GERON CORP [US], et al
- [Y] WO 0116312 A2 20010308 - RIBOZYME PHARM INC [US], et al
- [E] WO 03034985 A2 20030501 - UNIV ROCHESTER [US], et al
- [Y] ELBASHIR SAYDA M ET AL: "Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 411, no. 6836, 24 May 2001 (2001-05-24), pages 494 - 498, XP002206451, ISSN: 0028-0836
- [Y] ELBASHIR SAYDA M ET AL: "RNA interference is mediated by 21- and 22-nucleotide RNAs", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, NEW YORK, US, vol. 15, no. 2, 15 January 2001 (2001-01-15), pages 188 - 200, XP002204651, ISSN: 0890-9369
- [Y] BASS B L: "RNA interference: the short answer", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 411, 24 May 2001 (2001-05-24), pages 428 - 429, XP002239989, ISSN: 0028-0836
- [Y] ELBASHIR S M ET AL: "Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 20, no. 23, 3 December 2001 (2001-12-03), pages 6877 - 6888, XP002225998, ISSN: 0261-4189
- See references of WO 03070742A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR
DOCDB simple family (publication)
WO 03070742 A1 20030828; AU 2003215161 A1 20030909; EP 1432725 A1 20040630; EP 1432725 A4 20050330
DOCDB simple family (application)
US 0304088 W 20030211; AU 2003215161 A 20030211; EP 03710975 A 20030211