EP 1434573 A2 20040707 - IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF PAIN AND INFLAMMATION
Title (en)
IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF PAIN AND INFLAMMATION
Title (de)
SPÜLLÖSUNG UND VERFAHREN ZUR SCHMERZHINDERUNG UND ENTZÜNDUNGSHEMMUNG
Title (fr)
SOLUTION ET METHODE D'IRRIGATION DESTINEES A L'INHIBITION D'UNE DOULEUR ET D'UNE INFLAMMATION
Publication
Application
Priority
- US 9924558 W 19991020
- US 10504498 P 19981020
Abstract (en)
[origin: WO0023062A2] A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one neuronal nicotinic acetylcholine receptor agonist and, optionally, additional multiple pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a neuronal nicotinic acetylcholine receptor agonist, a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a mu -opioid agonist.
IPC 1-7
A61K 31/00; A61K 31/4406; A61K 31/4427; A61K 31/4439; A61K 31/444; A61K 31/675; A61K 31/439; A61K 45/06; A61P 29/00; A61K 31/465
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/439 (2006.01); A61K 31/4406 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/465 (2006.01); A61K 31/55 (2006.01); A61K 31/675 (2006.01); A61K 45/06 (2006.01)
CPC (source: EP)
A61K 31/00 (2013.01); A61K 31/439 (2013.01); A61K 31/4406 (2013.01); A61K 31/4427 (2013.01); A61K 31/4439 (2013.01); A61K 31/444 (2013.01); A61K 31/465 (2013.01); A61K 31/55 (2013.01); A61K 31/675 (2013.01); A61K 45/06 (2013.01); A61P 29/00 (2017.12)
Citation (search report)
See references of WO 0023062A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0023062 A2 20000427; WO 0023062 A3 20000727; AU 1214900 A 20000508; EP 1434573 A2 20040707
DOCDB simple family (application)
US 9924558 W 19991020; AU 1214900 A 19991020; EP 99970596 A 19991020