EP 1434797 A2 20040707 - INSULIN MIMETIC AMINO ACID SEQUENCES
Title (en)
INSULIN MIMETIC AMINO ACID SEQUENCES
Title (de)
INSULINMIMETISCHE AMINOSÄURESEQUENZEN
Title (fr)
SEQUENCES D'ACIDES AMINES INSULINOMIMETIQUES
Publication
Application
Priority
- DE 10149668 A 20011009
- EP 0211214 W 20021007
Abstract (en)
[origin: DE10149668A1] Exsulins (I) (insulin mimetic aminoacid sequences), having a molecular weight of up to 55000 Daltons and comprising 1-50 basic nonapeptide units (I') (same or different) and their phosphorylated, acetylated, farnesylated, oxidized, carbohydrate-conjugated, lipid-conjugated and solid- or liquid carrier-immobilized derivatives are new. Exsulins (I) (insulin mimetic aminoacid sequences), having a molecular weight of up to 55000 Daltons and comprising 1-50 basic units (same or different) of formula (-) (L, V, I, A)-X<1>-X<2>-(L, V, I, A)-(D, E)-(N, Q, M)-X<3>-(C, H)-X<4> (-) (I'), and their phosphorylated, acetylated, farnesylated, oxidized, carbohydrate-conjugated, lipid-conjugated and solid- or liquid carrier-immobilized derivatives are new. (L, V, I, A) = leucine (L), valine (V), isoleucine (I) or alanine (A); (D, E) = aspartic acid (D) or glutamic acid (E); (N, Q, M) = asparagine (N), glutamine (Q) or methionine (M); (C, H) = cysteine (C) or histidine (H); X<1>-X<4> = same or different aminoacid residues. The units (I') are in the middle or at the terminals of the chains, one of the bonds (-) being absent in terminal units. The bonds (-) (if present) link the (I') units to amino acids or amino acid sequences or link (I') units with each other directly or via an amino acid or amino acid sequence.
IPC 1-7
IPC 8 full level
C07K 14/62 (2006.01); A61K 38/28 (2006.01); A61K 38/30 (2006.01); A61P 5/48 (2006.01); C07K 14/415 (2006.01); C07K 14/47 (2006.01); C07K 14/475 (2006.01); C12N 15/17 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP US)
A61P 5/48 (2017.12 - EP); C07K 14/415 (2013.01 - EP US); C07K 14/4732 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)
Citation (search report)
See references of WO 03031472A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
DE 10149668 A1 20030410; EP 1434797 A2 20040707; PL 373834 A1 20050919; RU 2004114236 A 20050420; US 2005089969 A1 20050428; WO 03031472 A2 20030417; WO 03031472 A3 20040325
DOCDB simple family (application)
DE 10149668 A 20011009; EP 0211214 W 20021007; EP 02777293 A 20021007; PL 37383402 A 20021007; RU 2004114236 A 20021007; US 47618403 A 20031106