EP 1434850 A2 20040707 - HIGH-THROUGHPUT ELECTROPHYSIOLOGICAL MEASUREMENT SYSTEM
Title (en)
HIGH-THROUGHPUT ELECTROPHYSIOLOGICAL MEASUREMENT SYSTEM
Title (de)
ELEKTROPHYSIOLOGISCHES MESSSYSTEM MIT HOHEM DURCHSATZ
Title (fr)
SYSTEME DE MESURE ELECTROPHYSIOLOGIQUE DE GRANDE CAPACITE
Publication
Application
Priority
- US 0228398 W 20020905
- US 31711201 P 20010905
- US 0216122 W 20020521
- US 38319602 P 20020522
Abstract (en)
[origin: WO03021230A2] Systems, including apparatus and methods, for performing electrophysiological measurements on membranous samples, including living cells, isolated cell fragments (such as organelles), and/or artificial membranes (such as vesicles). The apparatus may include a high-throughput electrophysiological measurement system, and components thereof. This measurement system may include, among others, (1) a fluidics head for transferring samples and/or other compounds to a perforated measurement substrate, (2) a pressure-regulated plenum system for positioning samples on the substrate and subsequently forming a high-resistance electrical seal, (3) an activation system (such as a computer-controlled pulsed UV illumination module) for activating caged compounds, (4) an electronics head for applying and/or measuring voltage and/or current, and/or (5) a computer- controlled analysis system for collecting and/or analyzing data. The methods may include methods for performing high-throughput electrophysiological measurements on transporters and/or voltage or ligand-gated ion channels, sequentially and/or simultaneously.
IPC 1-7
IPC 8 full level
G01N 33/487 (2006.01); G01N 35/00 (2006.01); G01N 35/10 (2006.01)
CPC (source: EP)
G01N 33/48728 (2013.01); G01N 2035/00237 (2013.01); G01N 2035/1034 (2013.01)
Citation (search report)
See references of WO 03021230A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03021230 A2 20030313; WO 03021230 A3 20031030; EP 1434850 A2 20040707
DOCDB simple family (application)
US 0228398 W 20020905; EP 02780275 A 20020905