EP 1435789 A2 20040714 - HEMOCYANIN NUCLEIC ACIDS AND POLYPEPTIDES AND RELATED VECTORS, FUSION PROTEINS, CONJUGATES, CELLS AND METHODS OF USE
Title (en)
HEMOCYANIN NUCLEIC ACIDS AND POLYPEPTIDES AND RELATED VECTORS, FUSION PROTEINS, CONJUGATES, CELLS AND METHODS OF USE
Title (de)
HÄMOCYANIN-NUKLEINSÄUREN UND -POLYPEPTIDE UND DAMIT ZUSAMMENHÄNGENDE VEKTOREN, FUSIONSPROTEINE, KONJUGATE, ZELLEN UND VERFAHREN ZU IHRER VERWENDUNG
Title (fr)
ACIDES NUCLEIQUES D'HEMOCYANINE ET POLYPEPTIDES, VECTEURS ASSOCIES, PROTEINES DE FUSION, CONJUGUES, CELLULES ET PROCEDES D'UTILISATION
Publication
Application
Priority
- US 0228581 W 20020906
- US 31767801 P 20010906
- US 34541801 P 20011221
Abstract (en)
[origin: WO03023006A2] An isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence encoding KLH or a fragment thereof, as well as an isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence complementary thereto; a vector comprising such a nucleic acid, optionally as part of an encoded fusion protein when the nucleic acid encodes KLH or fragment thereof; a cell comprising and expressing an above-described nucleic acid, optionally in the form of a vector; an isolated or purified polypeptide molecule consisting essentially of an amino acid sequence encoding KLH-1, KLH-2, or a fragment of either of the foregoing, as well as a conjugate or fusion protein comprising the same and a therapeutically or prophylactically active agent, and related compositions; a method of treating cancer, pathogenic infection, and high blood pressure in a mammal; methods of stimulating an immune response in a mammal; a method of identifying an immunogenic portion of KLH, and an isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence encoding the leader sequence of KLH-1 or KLH-2, optionally coupled 5' to an isolated or purified nucleic acid molecule encoding a polypeptide or protein, in which case the nucleic acid is optionally in the form of a vector, as well as a eukaryotic cell comprising and expressing same.
IPC 1-7
A01N 63/00; A61K 48/00; C12N 5/00; C12N 5/02; C12N 15/00; C12N 15/09; C12N 15/63; C12N 15/70; C12N 15/74; C07H 21/04
IPC 8 full level
C07K 14/435 (2006.01); C12N 5/02 (2006.01)
CPC (source: EP US)
C07K 14/43504 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03023006 A2 20030320; WO 03023006 A3 20031120; AU 2002339902 A1 20030324; EP 1435789 A2 20040714; EP 1435789 A4 20050316; US 2004241695 A1 20041202
DOCDB simple family (application)
US 0228581 W 20020906; AU 2002339902 A 20020906; EP 02778241 A 20020906; US 48882404 A 20040305