Global Patent Index - EP 1436395 A4

EP 1436395 A4 20061213 - METHODS FOR IDENTIFYING AND USING MODULATORS OF ESTROGEN RELATED RECEPTOR GAMMA

Title (en)

METHODS FOR IDENTIFYING AND USING MODULATORS OF ESTROGEN RELATED RECEPTOR GAMMA

Title (de)

VERFAHREN ZUR IDENTIFIZIERUNG UND VERWENDUNG VON MODULATOREN DES ÖSTROGENVERWANDTEN REZEPTORS GAMMA

Title (fr)

METHODES D'IDENTIFICATION ET D'UTILISATION DE MODULATEURS DU RECEPTEUR GAMMA DEPENDANT DES OESTROGENES

Publication

EP 1436395 A4 20061213 (EN)

Application

EP 02776223 A 20021016

Priority

  • US 0232917 W 20021016
  • US 32988801 P 20011016

Abstract (en)

[origin: WO03034028A2] Methods of identifying compounds that interact with ERRy and are useful in the treatment of ERRy- and ER-mediated diseases, risk factors, and conditions are provided. Pharmaceutical compositions containing compounds that interact directly with ERRy and methods of using these compositions in the treatment of ERRy- and ER-mediated diseases, risk factors, and conditions are also provided.

IPC 1-7

C12N 15/12; C12N 15/63; C12N 5/00; C07K 14/00; G01N 33/574

IPC 8 full level

G01N 33/50 (2006.01); A61K 31/138 (2006.01); A61K 45/00 (2006.01); A61P 5/30 (2006.01); A61P 9/00 (2006.01); A61P 15/00 (2006.01); A61P 19/10 (2006.01); A61P 35/00 (2006.01); C12N 15/12 (2006.01); G01N 21/78 (2006.01); G01N 33/15 (2006.01); G01N 33/574 (2006.01); G01N 33/74 (2006.01)

CPC (source: EP)

A61P 5/30 (2018.01); A61P 9/00 (2018.01); A61P 15/00 (2018.01); A61P 19/10 (2018.01); A61P 35/00 (2018.01); G01N 33/574 (2013.01); G01N 33/743 (2013.01); G01N 2333/70567 (2013.01); G01N 2500/04 (2013.01); G01N 2800/108 (2013.01); G01N 2800/32 (2013.01); G01N 2800/362 (2013.01)

Citation (search report)

  • [X] COWARD P ET AL: "4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 98, no. 15, 17 July 2001 (2001-07-17), pages 8880 - 8884, XP002971442, ISSN: 0027-8424
  • [X] TREMBLAY G B ET AL: "4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related(ERR) nuclear receptors beta and gamma", ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 142, no. 10, 2001, pages 4572 - 4575, XP002967678, ISSN: 0013-7227
  • [A] SHIAU A K ET AL: "ORPHAN NUCLEAR RECEPTORS: FROM NEW LIGAND DISCOVERY TECHNOLOGIES TO NOVEL SIGNALING PATHWAYS", CURRENT OPINION IN DRUG DISCOVERY AND DEVELOPMENT, CURRENT DRUGS, LONDON, GB, vol. 4, no. 5, September 2001 (2001-09-01), pages 575 - 590, XP009031659, ISSN: 1367-6733
  • [A] HEARD D J ET AL: "Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult.", MOLECULAR ENDOCRINOLOGY (BALTIMORE, MD.) MAR 2000, vol. 14, no. 3, March 2000 (2000-03-01), pages 382 - 392, XP002404547, ISSN: 0888-8809
  • See also references of WO 03034028A3

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

Designated extension state (EPC)

LT LV RO SI

DOCDB simple family (publication)

WO 03034028 A2 20030424; WO 03034028 A3 20040219; AU 2002342058 A1 20030428; EP 1436395 A2 20040714; EP 1436395 A4 20061213; JP 2005509628 A 20050414

DOCDB simple family (application)

US 0232917 W 20021016; AU 2002342058 A 20021016; EP 02776223 A 20021016; JP 2003536715 A 20021016