EP 1438324 A1 20040721 - COHALOGENATIONS OF SELECTED DOUBLE BONDED COMPOUNDS USING N-HALO-SUCCINIMIDE.

Title (en)

COHALOGENATIONS OF SELECTED DOUBLE BONDED COMPOUNDS USING N-HALO-SUCCINIMIDE.

Title (de)

KOHALOGENIERUNG AUSGEWÄHLTER DOPPELBINDUNGSHALTIGER VERBINDUNGEN MIT N-HALOGENSUCCINIMID

Title (fr)

CO-HALOGENATION DE COMPOSES A DOUBLE LIAISON SELECTIONNES UTILISANT N-HALO-SUCCINIMIDE

Publication

EP 1438324 A1 20040721 (EN)

Application

EP 02799524 A 20020926

Priority

NZ 0200198 W 20020926
NZ 51446901 A 20010926
NZ 51566001 A 20011122

Abstract (en)

[origin: WO03027133A1] The present invention relates to a method of producing a cohalogenated compound by adding halogen(s) and another group(s) to a multiple bond in an initial compound, the method characterised by the step of reacting the initial compound with a primary reagent in the presence of a catalyst wherein the primary reagent reacts with the multiple bond to produce the cohalogenated compound. In preferred embodiments, the catalyst is hypophosphorous acid, the primary reagent consists of N-halo-succinimide and acetone and the initial compound is organic. This method is particularly applicable for the production of cohalogenated steroids, including lanosterol.

IPC 1-7

C07J 9/00; C07C 29/64; C07C 33/48; C07C 35/48

IPC 8 full level

C07C 29/64 (2006.01); C07J 9/00 (2006.01)

CPC (source: EP)

C07C 29/64 (2013.01); C07J 9/00 (2013.01); C12C 11/02 (2013.01); C07C 2601/14 (2017.04)

C-Set (source: EP)

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

DOCDB simple family (publication)

WO 03027133 A1 20030403; EP 1438324 A1 20040721; EP 1438324 A4 20050622

DOCDB simple family (application)

NZ 0200198 W 20020926; EP 02799524 A 20020926