Global Patent Index - EP 1438324 A4

EP 1438324 A4 20050622 - COHALOGENATIONS OF SELECTED DOUBLE BONDED COMPOUNDS USING N-HALO-SUCCINIMIDE.

Title (en)

COHALOGENATIONS OF SELECTED DOUBLE BONDED COMPOUNDS USING N-HALO-SUCCINIMIDE.

Title (de)

KOHALOGENIERUNG AUSGEWÄHLTER DOPPELBINDUNGSHALTIGER VERBINDUNGEN MIT N-HALOGENSUCCINIMID

Title (fr)

CO-HALOGENATION DE COMPOSES A DOUBLE LIAISON SELECTIONNES UTILISANT N-HALO-SUCCINIMIDE

Publication

EP 1438324 A4 20050622 (EN)

Application

EP 02799524 A 20020926

Priority

  • NZ 0200198 W 20020926
  • NZ 51446901 A 20010926
  • NZ 51566001 A 20011122

Abstract (en)

[origin: WO03027133A1] The present invention relates to a method of producing a cohalogenated compound by adding halogen(s) and another group(s) to a multiple bond in an initial compound, the method characterised by the step of reacting the initial compound with a primary reagent in the presence of a catalyst wherein the primary reagent reacts with the multiple bond to produce the cohalogenated compound. In preferred embodiments, the catalyst is hypophosphorous acid, the primary reagent consists of N-halo-succinimide and acetone and the initial compound is organic. This method is particularly applicable for the production of cohalogenated steroids, including lanosterol.

IPC 1-7

C07J 9/00; C07C 29/64; C07C 33/48; C07C 35/48

IPC 8 full level

C07C 29/64 (2006.01); C07J 9/00 (2006.01)

CPC (source: EP)

C07C 29/64 (2013.01); C07J 9/00 (2013.01); C12C 11/02 (2013.01); C07C 2601/14 (2017.04)

Citation (search report)

  • [X] PETR VANYSEK: "CRC Handbook of Chemistry and Physics, 76th Edition, pages 8-21 - 8-26", 1995, CRC PRESS, INC., XP002325661
  • [A] M.C. LU ET AL, J. MED. CHEM., vol. 14, no. 2, 1971, pages 136 - 138, XP002325659
  • [A] M. STEFANOVIC ET AL, GLASNIK HEMIJSKOG DRUSTVA BEOGRAD, vol. 31, no. 3, 1966, pages 139 - 147, XP008045667
  • [A] A. TENAGLIA ET AL, J. ORG. CHEM., vol. 61, no. 3, 1996, pages 1129 - 1132, XP002325660
  • [A] M. SMIETANA ET AL, TETRAHEDRON LETTERS, vol. 41, 2000, pages 193 - 195, XP004185446
  • [A] P.E. MALIGRES ET AL, TETRAHEDRON LETTERS, vol. 36, no. 13, 1995, pages 2195 - 2198, XP004028436
  • See references of WO 03027133A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

DOCDB simple family (publication)

WO 03027133 A1 20030403; EP 1438324 A1 20040721; EP 1438324 A4 20050622

DOCDB simple family (application)

NZ 0200198 W 20020926; EP 02799524 A 20020926