EP 1438402 A2 20040721 - MODULATORS OF BONE HOMEOSTASIS IDENTIFIED IN A HIGH-THROUGHPUT SCREEN
Title (en)
MODULATORS OF BONE HOMEOSTASIS IDENTIFIED IN A HIGH-THROUGHPUT SCREEN
Title (de)
DURCH EINEN SCREEN MIT HOHEM DURCHSATZ IDENTIFIZIERTE MODULATOREN DER KNOCHENHOMÖOSTASE
Title (fr)
MODULATEURS DE L'HOMEOSTASIE OSSEUSE IDENTIFIES DANS UN CRIBLAGE A HAUT RENDEMENT
Publication
Application
Priority
- EP 02796279 A 20020822
- EP 0209530 W 20020822
- EP 01870181 A 20010822
- US 31405601 P 20010822
- US 35693502 P 20020214
Abstract (en)
[origin: WO03018799A2] The invention relates to the field of molecular genetics and medicine. In particular, the present invention relates to the field of functional genomics, i.e., to a method for the identification of genes that function in regulating bone homeostasis, such as the induction of osteogenesis. In particular, the present invention relates to polynucleotides and the encoded polypeptides that are identified in a high-throughput screen designed to detect modulation of bone alkaline phosphatase activity. Moreover, the present invention relates to vectors, host cells, antibodies and diagnostic methods for detecting diseases involving the discovered polynucleotides, and therapeutic methods for treating such diseases. The invention further relates to methods and means for drug compound screens designed to develop new therapeutic strategies.
IPC 1-7
C12N 15/10; C12N 15/12; C07K 14/51; A61K 48/00; C07K 16/18; A61K 39/395; C12Q 1/68; A61K 38/17; A01K 67/027; G01N 33/68; G01N 33/50; A61K 31/70; C12N 15/11
IPC 8 full level
A01K 67/027 (2006.01); A61K 31/70 (2006.01); A61K 31/7088 (2006.01); A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 19/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 14/51 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/077 (2010.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/10 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
A61K 31/70 (2013.01); A61P 19/00 (2017.12); A61P 43/00 (2017.12); C07K 14/51 (2013.01); C07K 16/28 (2013.01); C12N 5/0654 (2013.01); G01N 33/6887 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); C07K 2317/21 (2013.01); C07K 2317/55 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01); C12N 2501/42 (2013.01); G01N 2500/04 (2013.01)
Citation (search report)
See references of WO 03018799A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03018799 A2 20030306; WO 03018799 A3 20040311; CA 2457879 A1 20030306; EP 1438402 A2 20040721; JP 2005503792 A 20050210
DOCDB simple family (application)
EP 0209530 W 20020822; CA 2457879 A 20020822; EP 02796279 A 20020822; JP 2003523648 A 20020822