EP 1438405 A1 20040721 - USE OF A DOUBLE-STRANDED RIBONUCLEIC ACID FOR SPECIFICALLY INHIBITING THE EXPRESSION OF A GIVEN TARGET GENE
Title (en)
USE OF A DOUBLE-STRANDED RIBONUCLEIC ACID FOR SPECIFICALLY INHIBITING THE EXPRESSION OF A GIVEN TARGET GENE
Title (de)
VERWENDUNG EINER DOPPELSTRÄNGIGEN RIBONUKLEINSÄURE ZUR GEZIELTEN HEMMUNG DER EXPRESSION EINES VORGEGEBENEN ZIELGENS
Title (fr)
UTILISATION D'UN ACIDE RIBONUCLEIQUE DOUBLE BRIN POUR INHIBER DE MANIERE CIBLEE L'EXPRESSION D'UN GENE CIBLE DETERMINE
Publication
Application
Priority
- EP 02779511 A 20021025
- DE 10100586 A 20010109
- DE 10155280 A 20011026
- DE 10158411 A 20011129
- DE 10160151 A 20011207
- DE 10235620 A 20020802
- EP 0211969 W 20021025
- EP 0200151 W 20020109
- EP 0200152 W 20020109
Abstract (en)
[origin: EP2264173A2] Using double-stranded RNA (dsRNA) for targeted inhibition of the expression, in a cell, of a specific target gene (A) that has a point mutation, relative to an original gene (A1), is new. One strand (S1) in dsRNA includes a region, complementary to (A), in which at least one nucleotide (nt) is not complementary and the number of nt that are not complementarty to A1 is at least 1 greater than the number not complementary to A. ACTIVITY : Cytostatic. No biological data given. MECHANISM OF ACTION : Binding of dsRNA to the target causes selective inhibition of oncogene expression.
IPC 1-7
IPC 8 full level
A61K 9/127 (2006.01); A61K 31/7105 (2006.01); A61K 31/7115 (2006.01); A61K 31/7125 (2006.01); A61K 31/713 (2006.01); A61K 47/34 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); A61P 5/00 (2006.01); A61P 9/00 (2006.01); A61P 25/28 (2006.01); A61P 31/12 (2006.01); A61P 33/06 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); A61P 37/02 (2006.01); A61P 43/00 (2006.01); C07H 21/02 (2006.01); C12N 15/09 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12N 15/88 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP US)
A61P 5/00 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 31/12 (2017.12 - EP); A61P 33/06 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/04 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C12N 15/111 (2013.01 - EP US); C12N 15/1131 (2013.01 - EP US); C12N 15/1138 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); C12N 2310/14 (2013.01 - EP US); C12N 2310/53 (2013.01 - EP US); C12N 2320/50 (2013.01 - EP US)
Citation (search report)
See references of WO 03035869A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
EP 2264173 A2 20101222; EP 2264173 A3 20150114; EP 1438405 A1 20040721
DOCDB simple family (application)
EP 10011813 A 20021025; EP 02779511 A 20021025