EP 1440073 A1 20040728 - PDE9 INHIBITORS FOR TREATING CARDIOVASCULAR DISORDERS
Title (en)
PDE9 INHIBITORS FOR TREATING CARDIOVASCULAR DISORDERS
Title (de)
PDE9 HEMMSTOFFE ZUR BEHANDLUNG KARDIOVASKULÄRER ERKRANKUNGEN
Title (fr)
INHIBITEURS PDE9 UTILISES DANS LE TRAITEMENT DES TROUBLES CARDIO-VASCULAIRES
Publication
Application
Priority
- GB 0126395 A 20011102
- GB 0130695 A 20011221
- GB 0216761 A 20020718
- IB 0204385 W 20021022
Abstract (en)
[origin: WO03037899A1] The invention relates to PDE9 inhibitors for treating cardiovascular disorders. Preferred PDE9 inhibitors are compounds of formula I wherein R1 is H or C1-6 alkyl, wherein R1 is attached to either N1 or N2 R2 is C1-6 alkyl optionally substituted by hydroxy or alkoxy C3-7 cycloalkyl optionally substituted by alkyl, hydroxy or alkoxy a saturated 5-6-membered heterocycle optionally substituted by alkyl, hydroxy or alkoxy het1 or Ar1 R3 is C1-6 alkyl optionally substituted by 1 or 2 groups independently selected from: Ar2 C3-7 cycloalkyl optionally substituted by C1-6 alkyl OAr2 SAr2 Sar2 NHCOC1-6 alkyl het2 xanthene and naphthalene I.
[origin: WO03037899A1] The invention relates to PDE9 inhibitors for treating cardiovascular disorders. Preferred PDE9 inhibitors are compounds of formula (I) wherein R<sp>1</sp> is H or C<sb>1−6</sb> alkyl, wherein R<sp>1</sp> is attached to either N<sp>1</sp> or N<sp>2</sp>; R<sp>2</sp> is C<sb>1−6</sb> alkyl optionally substituted by hydroxy or alkoxy; C<sb>3−7</sb> cycloalkyl optionally substituted by alkyl, hydroxy or alkoxy; a saturated 5−6−membered heterocycle optionally substituted by alkyl, hydroxy or alkoxy; het<sp>1</sp> or Ar<sp>1</sp>; R<sp>3</sp> is C<sb>1−6</sb> alkyl optionally substituted by 1 or 2 groups independently selected from: Ar<sp>2</sp>; C<sb>3−7</sb> cycloalkyl optionally substituted by C<sb>1−6</sb> alkyl; OAr<sp>2</sp>; SAr<sp>2</sp>; Sar<sp>2</sp>; NHC(O)C<sb>1−6</sb> alkyl; het<sp>2</sp>; xanthene; and naphthalene (I).
IPC 1-7
IPC 8 full level
A61K 31/519 (2006.01); A61K 45/00 (2006.01); A61P 1/04 (2006.01); A61P 3/10 (2006.01); A61P 7/00 (2006.01); A61P 7/02 (2006.01); A61P 7/06 (2006.01); A61P 7/08 (2006.01); A61P 9/00 (2006.01); A61P 9/04 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 9/14 (2006.01); A61P 11/00 (2006.01); A61P 11/02 (2006.01); A61P 11/04 (2006.01); A61P 11/06 (2006.01); A61P 11/16 (2006.01); A61P 13/02 (2006.01); A61P 13/08 (2006.01); A61P 13/10 (2006.01); A61P 13/12 (2006.01); A61P 15/00 (2006.01); A61P 15/04 (2006.01); A61P 15/06 (2006.01); A61P 15/08 (2006.01); A61P 15/10 (2006.01); A61P 17/02 (2006.01); A61P 17/06 (2006.01); A61P 17/14 (2006.01); A61P 25/00 (2006.01); A61P 25/02 (2006.01); A61P 25/28 (2006.01); A61P 27/02 (2006.01); A61P 27/06 (2006.01); A61P 27/14 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); A61P 37/08 (2006.01); A61P 39/00 (2006.01); A61P 43/00 (2006.01); C07B 61/00 (2006.01); C07D 487/04 (2006.01)
CPC (source: EP)
A61P 1/04 (2017.12); A61P 3/10 (2017.12); A61P 7/00 (2017.12); A61P 7/02 (2017.12); A61P 7/06 (2017.12); A61P 7/08 (2017.12); A61P 9/00 (2017.12); A61P 9/04 (2017.12); A61P 9/10 (2017.12); A61P 9/12 (2017.12); A61P 9/14 (2017.12); A61P 11/00 (2017.12); A61P 11/02 (2017.12); A61P 11/04 (2017.12); A61P 11/06 (2017.12); A61P 11/16 (2017.12); A61P 13/02 (2017.12); A61P 13/08 (2017.12); A61P 13/10 (2017.12); A61P 13/12 (2017.12); A61P 15/00 (2017.12); A61P 15/04 (2017.12); A61P 15/06 (2017.12); A61P 15/08 (2017.12); A61P 15/10 (2017.12); A61P 17/02 (2017.12); A61P 17/06 (2017.12); A61P 17/14 (2017.12); A61P 25/00 (2017.12); A61P 25/02 (2017.12); A61P 25/28 (2017.12); A61P 27/02 (2017.12); A61P 27/06 (2017.12); A61P 27/14 (2017.12); A61P 35/00 (2017.12); A61P 35/04 (2017.12); A61P 37/08 (2017.12); A61P 39/00 (2017.12); A61P 43/00 (2017.12); C07D 487/04 (2013.01)
Citation (search report)
See references of WO 03037899A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03037899 A1 20030508; AR 037329 A1 20041103; BR 0214096 A 20040928; CA 2466824 A1 20030508; DO P2002000482 A 20030531; EP 1440073 A1 20040728; HN 2002000317 A 20030521; JP 2005511575 A 20050428; MX PA04004171 A 20040906; PA 8557401 A1 20031112; PE 20030702 A1 20030821; SV 2004001373 A 20040107; TW 200300081 A 20030516; UY 27522 A1 20030630
DOCDB simple family (application)
IB 0204385 W 20021022; AR P020104152 A 20021031; BR 0214096 A 20021022; CA 2466824 A 20021022; DO 2002000482 A 20021009; EP 02777623 A 20021022; HN 2002000317 A 20021001; JP 2003540180 A 20021022; MX PA04004171 A 20021022; PA 8557401 A 20021029; PE 2002001070 A 20021030; SV 2002001373 A 20021101; TW 91132424 A 20021101; UY 27522 A 20021030