EP 1440158 A1 20040728 - METHOD FOR THE PRODUCTION OF (R)- AND (S)-8-CHLORO-6-HYDROXY-OCTANIC ACID ALKYL ESTERS BY ENZYMATIC REDUCTION
Title (en)
METHOD FOR THE PRODUCTION OF (R)- AND (S)-8-CHLORO-6-HYDROXY-OCTANIC ACID ALKYL ESTERS BY ENZYMATIC REDUCTION
Title (de)
VERFAHREN ZUR HERSTELLUNG VON (R)- UND (S)-8-CHLOR-6-HYDROXY-OCTANSÄUREALKYLESTERN DURCH ENZYMATISCHE REDUKTION
Title (fr)
PROCEDE DE FABRICATION D'ESTERS D'ALKYLE D'ACIDE 8-CHLORO-6-HYDROXY-OCTANOIQUE (R) ET (S) PAR REDUCTION ENZYMATIQUE
Publication
Application
Priority
- DE 10152113 A 20011023
- EP 0211470 W 20021014
Abstract (en)
[origin: DE10152113C1] Preparation of alkyl (R)- or (S)-8-chloro-6-hydroxy-octanoates (II) involves enzymatic reduction of alkyl 8-chloro-6-oxo-octanoates (I) using alcohol dehydrogenases or carbonyl reductases in presence of NAD(H) or NADP(H) as cofactor. Preparation of alkyl (R)- or (S)-8-chloro-6-hydroxy-octanoates of formula (II), comprises enzymatic reduction of alkyl 8-chloro-6-oxo-octanoates of formula (I) using alcohol dehydrogenases or carbonyl reductases in presence of nicotinamide adenine dinucleotide NAD(H) or nicotinamide adenine dinucleotide phosphate NADP(H) as cofactor. R = 1-4C alkyl. An Independent claim is included for the preparation of (R)- or (S)- alpha -lipoic acid, by conventional conversion of (II) obtained by the above process.
IPC 1-7
IPC 8 full level
C07D 339/04 (2006.01); C12P 1/00 (2006.01); C12P 7/42 (2006.01); C12P 7/62 (2006.01); C12P 17/00 (2006.01); C12R 1/01 (2006.01)
CPC (source: EP US)
C12P 1/00 (2013.01 - EP US); C12P 7/42 (2013.01 - EP US); C12P 7/62 (2013.01 - EP US)
Citation (search report)
See references of WO 03035885A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
DE 10152113 C1 20030306; EP 1440158 A1 20040728; JP 2005506091 A 20050303; US 2005032180 A1 20050210; US 7157253 B2 20070102; WO 03035885 A1 20030501
DOCDB simple family (application)
DE 10152113 A 20011023; EP 0211470 W 20021014; EP 02779483 A 20021014; JP 2003538385 A 20021014; US 49363004 A 20041005