EP 1442034 A1 20040804 - BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS KDR PROTEIN KINASE INHIBITORS
Title (en)
BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS KDR PROTEIN KINASE INHIBITORS
Title (de)
BENZIMIDAZOLDERIVATE UND IHRE VERWENDUNG ALS PROTEINKINASE-KDR-INHIBITOREN
Title (fr)
DERIVES DE BENZIMIDAZOLES ET LEUR UTILISATION COMME INHIBITEURS DE PROTEINE KINASE KDR
Publication
Application
Priority
- FR 0203647 W 20021024
- FR 0113867 A 20011026
Abstract (en)
[origin: WO03035644A1] The invention concerns novel products of formula (IA), wherein: A represents an optionally substituted cyclic or bicyclic saturated heterocycle, in particular pyrazole or imidazole, optionally substituted; A1, A2, A3 and A4, identical or different, are in particular selected among hydrogen, halogen, hydroxyl, alkyl and alkoxy, nitro, cyano, phenyl, phenoxy, free carboxy, salified, esterified by an alkyl radical or amidified to form CONA6A7 cyclized or not, with two among A1b, A2b, A3b and A4b capable of forming with the benzimidazole radical a cycle containing one or several heteroatoms; A5 represents hydrogen or alkyl, said products being in all isomeric forms and the salts as medicines in particular KDR inhibitors.
IPC 1-7
C07D 405/14; C07D 401/14; C07D 403/04; C07D 409/14; C07D 491/04; C07D 403/14; A61K 31/4184; A61P 35/00
IPC 8 full level
C07D 491/056 (2006.01); A61K 31/4184 (2006.01); A61K 31/4188 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61P 3/00 (2006.01); A61P 3/10 (2006.01); A61P 7/02 (2006.01); A61P 9/10 (2006.01); A61P 11/06 (2006.01); A61P 17/06 (2006.01); A61P 19/02 (2006.01); A61P 21/00 (2006.01); A61P 25/00 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 487/04 (2006.01); C07D 491/04 (2006.01); C07D 491/052 (2006.01); C07D 521/00 (2006.01)
CPC (source: EP US)
A61P 3/00 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 7/02 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 17/06 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/08 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 231/12 (2013.01 - EP US); C07D 233/56 (2013.01 - EP US); C07D 249/08 (2013.01 - EP US); C07D 401/14 (2013.01 - EP US); C07D 403/04 (2013.01 - EP US); C07D 403/14 (2013.01 - EP US); C07D 405/14 (2013.01 - EP US); C07D 409/14 (2013.01 - EP US); C07D 487/04 (2013.01 - EP US); C07D 491/04 (2013.01 - EP US)
Citation (search report)
See references of WO 03035644A1
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
WO 03035644 A1 20030501; CA 2466813 A1 20030501; EP 1442034 A1 20040804; FR 2831536 A1 20030502; JP 2005509639 A 20050414; JP 2009167219 A 20090730; JP 4377228 B2 20091202; MX PA04003381 A 20040618; US 2005009894 A1 20050113; US 2008125418 A1 20080529
DOCDB simple family (application)
FR 0203647 W 20021024; CA 2466813 A 20021024; EP 02791892 A 20021024; FR 0113867 A 20011026; JP 2003538160 A 20021024; JP 2009112407 A 20090507; MX PA04003381 A 20021024; US 82801204 A 20040420; US 94300807 A 20071120