EP 1448183 A2 20040825 - TREATMENT OF NEURODEGENERATIVE DISORDERS THROUGH THE MODULATION OF THE POLYAMINE PATHWAY
Title (en)
TREATMENT OF NEURODEGENERATIVE DISORDERS THROUGH THE MODULATION OF THE POLYAMINE PATHWAY
Title (de)
BEHANDLUNG VON NEURODEGENERATIVEN ERKRANKUNGEN DURCH MODULIEREN DES POLYAMINENBIOSYNTHESEWEGS
Title (fr)
TRAITEMENT DE TROUBLES NEURODEGENERATIFS PAR MODULATION DE LA VOIE POLYAMINE
Publication
Application
Priority
- US 0235203 W 20021101
- US 33326301 P 20011116
Abstract (en)
[origin: WO03043616A2] The present invention provides methods and compositions for modulating polyamine pathway activity as a means for ameliorating neurodegenarative disorders. In particular, for ameliorating the symptoms or onset of amyotrophic lateral sclerosis (ALS) by modulating the gene and protein products involved the polyamine pathway, such as by inhibiting the enzyme, ornithine decarboxylase (ODC), involved in the synthesis of the polyamine, putrescine. Compositions and methods are disclosed for inhibiting the polyamine pathway producing lower polyamine levels resulting in a beneficial effect on ALS. This can be accomplished by using modulating agents such as analogs, or polyamine analogs, and antiproliferative drugs. Screening assays for pharmacological agents that are capable of decreasing polyamine levels and/or reducing cell proliferation are also disclosed.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/13 (2006.01); A61K 31/132 (2006.01); A61K 31/135 (2006.01); A61K 31/17 (2006.01); A61K 31/198 (2006.01); A61K 31/216 (2006.01)
CPC (source: EP)
A61K 31/00 (2013.01); A61K 31/13 (2013.01); A61K 31/132 (2013.01); A61K 31/135 (2013.01); A61K 31/17 (2013.01); A61K 31/198 (2013.01); A61K 31/216 (2013.01); G01N 2333/70535 (2013.01); G01N 2333/70596 (2013.01); G01N 2500/04 (2013.01); G01N 2500/10 (2013.01)
Citation (search report)
See references of WO 03043616A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03043616 A2 20030530; WO 03043616 A3 20031016; EP 1448183 A2 20040825
DOCDB simple family (application)
US 0235203 W 20021101; EP 02780564 A 20021101