EP 1448527 A1 20040825 - METHOD OF RESOLVING AMLODIPINE RACEMATE
Title (en)
METHOD OF RESOLVING AMLODIPINE RACEMATE
Title (de)
VERFAHREN ZUR SPALTUNG EINES AMYLODIPINRACEMATS
Title (fr)
PROCEDE DE RESOLUTION DE RACEMATE D'AMLODIPINE
Publication
Application
Priority
- US 0233894 W 20021023
- US 34625001 P 20011024
Abstract (en)
[origin: WO03035623A1] The invention relates to methods of resolving racemic amlodipine into enantiomerically enriched compositions by precipation with tartaric acid in the presence of a non-aqueous solvent, such as N,N'-dimethylacetamide. The molar ratio of tartaric acid:amlodipine is preferably less than 0.25:1.0 greater than 0.75:1.0.
IPC 1-7
IPC 8 full level
A61K 31/4422 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); C07D 211/90 (2006.01)
CPC (source: EP KR US)
A61P 9/10 (2018.01 - EP); A61P 9/12 (2018.01 - EP); C07D 211/90 (2013.01 - EP KR US); C07D 213/46 (2013.01 - KR)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03035623 A1 20030501; BR 0213505 A 20041019; CA 2466806 A1 20030501; CN 1608051 A 20050420; CZ 2004531 A3 20041013; EP 1448527 A1 20040825; HU P0401887 A2 20050128; HU P0401887 A3 20050530; IL 161448 A0 20040927; JP 2005509637 A 20050414; KR 20040062575 A 20040707; MX PA04003877 A 20050217; NZ 532316 A 20051028; PL 369406 A1 20050418; RU 2004116064 A 20051120; US 2003130321 A1 20030710; US 2005009887 A1 20050113; US 6822099 B2 20041123; ZA 200403052 B 20051118
DOCDB simple family (application)
US 0233894 W 20021023; BR 0213505 A 20021023; CA 2466806 A 20021023; CN 02825939 A 20021023; CZ 2004531 A 20021023; EP 02802193 A 20021023; HU P0401887 A 20021023; IL 16144802 A 20021023; JP 2003538139 A 20021023; KR 20047005925 A 20021023; MX PA04003877 A 20021023; NZ 53231602 A 20021023; PL 36940602 A 20021023; RU 2004116064 A 20021023; US 32568602 A 20021220; US 91136104 A 20040804; ZA 200403052 A 20040421