EP 1448583 A4 20060208 - A NOVEL G PROTEIN-COUPLED RECEPTOR, GAVE8
Title (en)
A NOVEL G PROTEIN-COUPLED RECEPTOR, GAVE8
Title (de)
GAVE8, EIN NEUER G-PROTEIN-GEKOPPELTER REZEPTOR
Title (fr)
NOUVEAU RECEPTEUR COUPLE AUX PROTEINES G, GAVE8
Publication
Application
Priority
- GB 0125704 A 20011026
- US 0223208 W 20020719
- US 30643401 P 20010720
Abstract (en)
[origin: WO03008560A2] Novel GAVE8 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length GAVE8 proteins, isolated GAVE8 fusion proteins, antigenic peptides and anti-GAVE8 are provided.The invention also provides GAVE8 nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecule, host cells into which the expression vectors have been introduced and nonhuman transgenic animals in which GAVE8 gene has been introduced or disrupted are described. Diagnostic, screening, and therapeutic methods utilizing GAVE8 compositions or molecules binding GAVE8 also are provided. Methods for identifying GAVE8 agonists, antagonists, inverse agonists and the like are described.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 45/00 (2006.01); A61P 1/00 (2006.01); A61P 9/04 (2006.01); A61P 9/08 (2006.01); A61P 11/08 (2006.01); C07K 14/705 (2006.01); C07K 14/72 (2006.01); C07K 16/28 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 1/00 (2017.12); A61P 9/04 (2017.12); A61P 9/08 (2017.12); A61P 11/08 (2017.12); C07K 14/723 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
- [X] WO 0136473 A2 20010525 - UPJOHN CO [US], et al
- [PX] WO 0181573 A1 20011101 - AVENTIS PHARMA GMBH [DE]
- [PX] WO 0200719 A2 20020103 - TULARIK INC [US], et al
- [X] DATABASE EMBL [online] 6 December 2000 (2000-12-06), "Homo sapiens sphingosine 1-phosphate receptor Edg-8 gene, complete cds.", XP002357167, retrieved from EBI accession no. EM_PRO:AF317676 Database accession no. AF317676
- [X] LIU C H ET AL: "The Mouse Gene for the Inducible G-Protein-Coupled Receptoredg-1", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 43, no. 1, 1 July 1997 (1997-07-01), pages 15 - 24, XP004459267, ISSN: 0888-7543
- [PX] DATABASE Geneseq [online] 25 February 2002 (2002-02-25), "Human EDG-8 receptor protein.", XP002357215, retrieved from EBI accession no. GSN:AAG80582 Database accession no. AAG80582
- [DA] GOETZL E J ET AL: "A SUBFAMILY OF G PROTEIN-COUPLED CELLULAR RECEPTORS FOR LYSOPHOSPHOLIPIDS AND LYSOSPHINGOLIPIDS", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, SPRING ST., NY, US, vol. 469, 1999, pages 259 - 264, XP002944908, ISSN: 0065-2598 & DATABASE Geneseq [online] 28 August 2001 (2001-08-28), "Human nGPCR9 #2.", XP002357168, retrieved from EBI accession no. GSN:AAG80967 Database accession no. AAG80967 & DATABASE Geneseq [online] 25 February 2002 (2002-02-25), "Human EDG8 receptor protein.", XP002357169, retrieved from EBI accession no. GSN:AAG80590 Database accession no. AAG80590 & DATABASE Geneseq [online] 9 April 2002 (2002-04-09), "Amino acid sequence of human G-protein coupled receptor edg protein.", XP002357214, retrieved from EBI accession no. GSN:AAU74910 Database accession no. AAU74910
- See references of WO 03008560A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03008560 A2 20030130; WO 03008560 A8 20040624; BR 0211338 A 20041116; CA 2454427 A1 20030130; EP 1448583 A2 20040825; EP 1448583 A4 20060208; IL 159939 A0 20040620; JP 2005522184 A 20050728; MX PA04000437 A 20040318; NO 20040252 L 20040319; TW I250209 B 20060301
DOCDB simple family (application)
US 0223208 W 20020719; BR 0211338 A 20020719; CA 2454427 A 20020719; EP 02747073 A 20020719; IL 15993902 A 20020719; JP 2003514877 A 20020719; MX PA04000437 A 20020719; NO 20040252 A 20040119; TW 91116166 A 20020719