EP 1450862 A1 20040901 - REPLICATION COMPETENT DUAL-AD VECTORS FOR VACCINE AND IMMUNOTHERAPY APPLICATIONS
Title (en)
REPLICATION COMPETENT DUAL-AD VECTORS FOR VACCINE AND IMMUNOTHERAPY APPLICATIONS
Title (de)
REPLIKATIONSFÄHIGE DUAL-AD-VEKTOREN FÜR VAKZINE UND IMMUNOTHERAPEUTISCHE ANWENDUNGEN
Title (fr)
PAIRE DE VECTEURS ADENOVIRAUX APPROPRIES POUR LA REPLICATION DESTINES A DES VACCINS ET DES APPLICATIONS D'IMMUNOTHERAPIE
Publication
Application
Priority
- US 0233162 W 20021016
- US 32979801 P 20011016
Abstract (en)
[origin: WO03033029A1] A composition for targeting one or more infectious agent(s) or target cell(s) comprising a complementary set of adenoviral vectors, wherein each vector is dependent upon the other for replication. The first vector of the pair may comprise an E1 expression cassette where E1 is expressed within one or more infectious agent(s) or target cell(s) from a promoter and does not express other adenoviral proteins. The second vector provides adenoviral proteins required for packaging and replication. As such, the composition is useful for the delivery and expression of prophylactic and/or therapeutic genes, some of which demonstrate direct cytotoxic effects, indirect cytotoxic effects, or sensitize target cells to the effects of other treatments. The composition may encode one or more antigen(s), with or without immunomodulatory genes, to induce one or more immune response(s) to the encoded antigen or antigens.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 31/7088 (2006.01); A61K 35/76 (2006.01); A61K 39/00 (2006.01); A61K 39/235 (2006.01); A61K 48/00 (2006.01); A61P 9/00 (2006.01); A61P 31/00 (2006.01); A61P 31/18 (2006.01); A61P 35/00 (2006.01); A61P 37/04 (2006.01); A61P 37/06 (2006.01); A61P 43/00 (2006.01); C12N 15/861 (2006.01)
CPC (source: EP)
A61K 39/12 (2013.01); A61K 39/235 (2013.01); A61K 48/00 (2013.01); A61P 9/00 (2017.12); A61P 31/00 (2017.12); A61P 31/18 (2017.12); A61P 35/00 (2017.12); A61P 37/04 (2017.12); A61P 37/06 (2017.12); A61P 43/00 (2017.12); C12N 15/86 (2013.01); A61K 2039/5256 (2013.01); A61K 2039/53 (2013.01); C12N 2710/10343 (2013.01); C12N 2710/10345 (2013.01); C12N 2830/008 (2013.01); C12N 2830/38 (2013.01); C12N 2830/42 (2013.01); C12N 2830/85 (2013.01); C12N 2840/20 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03033029 A1 20030424; AU 2002365260 A1 20030902; AU 2002365260 A8 20071220; CA 2463996 A1 20030424; EP 1450862 A1 20040901; EP 1450862 A4 20050302; JP 2005511534 A 20050428; WO 03061560 A2 20030731; WO 03061560 A3 20071018
DOCDB simple family (application)
US 0233162 W 20021016; AU 2002365260 A 20021016; CA 2463996 A 20021016; EP 02770603 A 20021016; JP 2003535831 A 20021016; US 0233079 W 20021016