EP 1450864 A2 20040901 - CONJUGATES OF MACROCYCLIC METAL COMPLEXES WITH BIOMOLECULES AND THE UTILIZATION THEREOF FOR PRODUCING AGENTS FOR USE IN NMR DIAGNOSIS AND RADIODIAGNOSIS AND RADIOTHERAPY
Title (en)
CONJUGATES OF MACROCYCLIC METAL COMPLEXES WITH BIOMOLECULES AND THE UTILIZATION THEREOF FOR PRODUCING AGENTS FOR USE IN NMR DIAGNOSIS AND RADIODIAGNOSIS AND RADIOTHERAPY
Title (de)
KONJUGATE MAKROCYCLISCHER METALLKOMPLEXE MIT BIOMOLEKÜLEN UND DEREN VERWENDUNG ZUR HERSTELLUNG VON MITTELN FÜR NMR- UND RADIODIAGNOSTIK SOWIE DIE RADIOTHERAPIE
Title (fr)
CONJUGUES DE COMPLEXES METALLIQUES MACROCYCLIQUES CONTENANT DES BIOMOLECULES ET LEUR UTILISATION DANS LA PRODUCTION D'AGENTS DESTINES AU RADIODIAGNOSTIC ET AU DIAGNOSTIC PAR RESONANCE MAGNETIQUE AINSI QU'A LA RADIOTHERAPIE
Publication
Application
Priority
- DE 10135355 A 20010720
- EP 0208000 W 20020718
Abstract (en)
[origin: WO03013617A2] The invention relates to conjugates comprised of macrocyclic metal complexes with biomolecules and to the production thereof. The conjugates are suited for use as contrast agents in NMR diagnosis and radiodiagnosis and as agents for radiotherapy. A high relaxivity is achieved and a fine tuning of the relaxivity is made possible by a special liganding of the macrocycles.
IPC 1-7
IPC 8 full level
A61K 47/48 (2006.01); A61K 49/00 (2006.01); A61K 49/08 (2006.01); A61K 51/00 (2006.01); C07D 301/00 (2006.01)
CPC (source: EP KR US)
A61K 49/0002 (2013.01 - EP US); A61K 49/085 (2013.01 - EP US); A61K 49/14 (2013.01 - EP US); A61K 49/143 (2013.01 - EP US); C07D 257/02 (2013.01 - KR)
Citation (search report)
See references of WO 03013617A2
Citation (examination)
- WO 9531444 A1 19951123 - BRACCO INT BV [NL]
- EP 0565930 A1 19931020 - NIHON MEDIPHYSICS CO LTD [JP]
- WOODS ET AL: "Correlation of water exchange rate with isomeric composition in diastereoisomeric Gd complexes of tetra(carboxyethyl)dota and related macrocyclic ligands", JACS, vol. 122, no. 40, 2000, pages 9781 - 9792, XP009058154, DOI: doi:10.1021/ja994492v
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03013617 A2 20030220; WO 03013617 A3 20040610; AR 036182 A1 20040818; AU 2002355333 B2 20070104; BR 0211150 A 20040629; CA 2453214 A1 20030220; CN 1301750 C 20070228; CN 1541114 A 20041027; DE 10135355 C1 20030417; EP 1450864 A2 20040901; IL 159291 A0 20040601; JP 2004536889 A 20041209; KR 20040030825 A 20040409; MX PA04000400 A 20040318; NO 20040239 L 20040119; PE 20030190 A1 20030322; PL 366421 A1 20050124; RU 2004105262 A 20050710; TW I238722 B 20050901; US 2003206865 A1 20031106; US 2007014725 A1 20070118; UY 27389 A1 20030228
DOCDB simple family (application)
EP 0208000 W 20020718; AR P020102718 A 20020719; AU 2002355333 A 20020718; BR 0211150 A 20020718; CA 2453214 A 20020718; CN 02814569 A 20020718; DE 10135355 A 20010720; EP 02794507 A 20020718; IL 15929102 A 20020718; JP 2003518619 A 20020718; KR 20047000905 A 20020718; MX PA04000400 A 20020718; NO 20040239 A 20040119; PE 2002000641 A 20020719; PL 36642102 A 20020718; RU 2004105262 A 20020718; TW 91116146 A 20020719; US 19804802 A 20020719; US 39041406 A 20060328; UY 27389 A 20020717