Global Patent Index - EP 1453803 A2

EP 1453803 A2 20040908 - TETRAHYDROCARBOZOLE DERIVATIVES AS LIGANDS FOR G-PROTEIN COUPLED RECEPTORS (GPCR)

Title (en)

TETRAHYDROCARBOZOLE DERIVATIVES AS LIGANDS FOR G-PROTEIN COUPLED RECEPTORS (GPCR)

Title (de)

TETRAHYDROCARBAZOLDERIVATE ALS LIGANDEN FÜR G-PROTEIN GEKOPPELTE REZEPTOREN (GPCR)

Title (fr)

DERIVES TETRAHYDROCARBAZOL SERVANT DE LIGANDS DE RECEPTEURS COUPLES AUX PROTEINES G (GPCR)

Publication

EP 1453803 A2 20040908 (DE)

Application

EP 02796648 A 20021216

Priority

  • DE 10164564 A 20011214
  • EP 0214344 W 20021216
  • US 34187801 P 20011221

Abstract (en)

[origin: WO03051837A2] The invention relates to novel tetrahydrocarbozole derivatives acting as ligands for G-protein coupled receptors (GPCR), especially as antagonists of gonadotropin-releasing hormone (GnRH). The invention also relates to a pharmaceutical composition containing said novel tetrahydrocarbozole derivatives, and to a method for producing the same. Furthermore, the invention relates to the administration of tetrahydrocarbozole derivatives for the treatment of pathological conditions mediated by GPCR, especially for the inhibition of GnRH, to mammals, especially humans, requiring such treatment, and to the use of tetrahydrocarbozole derivatives for producing a pharmaceutical agent for treating pathological conditions mediated by GPCR, especially for the inhibition of GnRH.

IPC 1-7

C07D 209/88; A61K 31/403; A61P 15/00; C07D 209/86

IPC 8 full level

C07D 401/06 (2006.01); A61K 31/403 (2006.01); A61K 31/4439 (2006.01); A61K 38/00 (2006.01); A61P 15/00 (2006.01); A61P 15/08 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 209/00 (2006.01); C07D 209/86 (2006.01); C07D 209/88 (2006.01); C07D 401/12 (2006.01); C07K 5/02 (2006.01)

CPC (source: EP)

A61P 5/00 (2018.01); A61P 15/00 (2018.01); A61P 15/08 (2018.01); A61P 15/16 (2018.01); A61P 15/18 (2018.01); A61P 35/00 (2018.01); A61P 43/00 (2018.01); C07D 209/86 (2013.01); C07D 209/88 (2013.01); C07D 401/12 (2013.01); C07K 5/0202 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 03051837A3

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR

DOCDB simple family (publication)

WO 03051837 A2 20030626; WO 03051837 A3 20040226; WO 03051837 A8 20040506; AR 037863 A1 20041209; AU 2002361430 A1 20030630; AU 2002361430 B2 20070913; BR 0214958 A 20041228; CA 2468880 A1 20030626; CN 100500654 C 20090617; CN 1599720 A 20050323; EP 1453803 A2 20040908; HR P20040609 A2 20050630; HU 0500014 A2 20050428; HU 0500014 A3 20100628; IL 161626 D0 20040927; IL 192991 D0 20110801; JP 2005518375 A 20050623; MX PA04005768 A 20040910; NO 20042198 L 20040709; NO 326692 B1 20090202; NZ 533430 A 20051223; PL 373400 A1 20050822; RU 2004121776 A 20050510; RU 2319692 C2 20080320; TW 200305405 A 20031101; TW I246423 B 20060101

DOCDB simple family (application)

EP 0214344 W 20021216; AR P020104893 A 20021217; AU 2002361430 A 20021216; BR 0214958 A 20021216; CA 2468880 A 20021216; CN 02824148 A 20021216; EP 02796648 A 20021216; HR P20040609 A 20040705; HU 0500014 A 20021216; IL 16162602 A 20021216; IL 19299108 A 20080723; JP 2003552724 A 20021216; MX PA04005768 A 20021216; NO 20042198 A 20040526; NZ 53343002 A 20021216; PL 37340002 A 20021216; RU 2004121776 A 20021216; TW 91136440 A 20021216