EP 1453976 A2 20040908 - METHOD FOR ANALYZING TRANSLATION-CONTROLLED GENE EXPRESSION
Title (en)
METHOD FOR ANALYZING TRANSLATION-CONTROLLED GENE EXPRESSION
Title (de)
VERFAHREN ZUR ANALYSE DER TRANSLATIONSKONTROLLIERTEN GENEXPRESSION
Title (fr)
PROCEDE D'ANALYSE DE L'EXPRESSION DE GENES COMMANDEE PAR TRANSLATION
Publication
Application
Priority
- DE 10158517 A 20011129
- EP 0213214 W 20021125
Abstract (en)
[origin: WO03046214A2] The invention relates to a method for analyzing gene expression, enabling a reliable correlation of the amount of mRNA transcribed by the gene to be examined, taking into account the translation state present in a cell type, tissue or organism, with the amount of protein which is translated from said mRNA. Determination of the translation efficiency of all mRNA variants which are transcribed by a gene to be examined, coding for a specific protein enables inter alia identification of the preferentially translated mRNA variant in a specific cell type, tissue or organism. It is possible to make a reliable forecast of the amount of protein expressed in a cell type, tissue or organism on the basis of the amount and translation efficiency of the preferentially translated mRNA variant coding for a protein to be examined.
IPC 1-7
IPC 8 full level
G01N 33/53 (2006.01); C12M 1/00 (2006.01); C12M 1/34 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6886 (2018.01); G01N 33/58 (2006.01); G01N 37/00 (2006.01)
CPC (source: EP US)
C12Q 1/6886 (2013.01 - EP US); C12Q 2600/158 (2013.01 - EP US)
Citation (search report)
See references of WO 03046214A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03046214 A2 20030605; WO 03046214 A3 20040401; AU 2002358532 A1 20030610; CA 2468409 A1 20030605; CN 1615369 A 20050511; DE 10158517 A1 20030612; EP 1453976 A2 20040908; JP 2005510247 A 20050421; US 2005037357 A1 20050217
DOCDB simple family (application)
EP 0213214 W 20021125; AU 2002358532 A 20021125; CA 2468409 A 20021125; CN 02827488 A 20021125; DE 10158517 A 20011129; EP 02792796 A 20021125; JP 2003547645 A 20021125; US 49712804 A 20041008