EP 1455812 A4 20060322 - ANTAGONIST ANTI-CD40 MONOCLONAL ANTIBODY THERAPY FOR MULTIPLE SCLEROSIS TREATMENT
Title (en)
ANTAGONIST ANTI-CD40 MONOCLONAL ANTIBODY THERAPY FOR MULTIPLE SCLEROSIS TREATMENT
Title (de)
BEHANDLUNG MIT ANTI-CD40 MONOKLONALEM ANTIKÖRPER FÜR DIE BEHANDLUNG VON MULTIPLER SKLEROSE
Title (fr)
TRAITEMENT AUX ANTICORPS MONOCLONAUX ANTI-CD40 ANTAGONISTES UTILISE POUR TRAITER LA SCLEROSE EN PLAQUES
Publication
Application
Priority
- US 0238164 W 20021126
- US 33335501 P 20011126
Abstract (en)
[origin: WO03045978A2] The present invention is directed to a method for preventing or alleviating the symptons of MS by delivering to the central nervous system an interferon and an anti-CD40 antibody. Interferons include interferon- beta and its muteins such as IFN- beta ser17.
IPC 1-7
IPC 8 full level
A61K 38/21 (2006.01); A61K 39/395 (2006.01); A61P 1/04 (2006.01); A61P 25/00 (2006.01); A61P 37/02 (2006.01); C07K 16/28 (2006.01)
CPC (source: EP)
A61K 39/39541 (2013.01); A61P 1/04 (2017.12); A61P 25/00 (2017.12); A61P 37/02 (2017.12); C07K 16/2878 (2013.01); A61K 2039/505 (2013.01)
Citation (search report)
- [X] WO 0137870 A1 20010531 - KENNEDY RHEUMATOLOGY INST [GB], et al
- [X] GERRITSE K ET AL: "CD40-CD40 LIGAND INTERACTIONS IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS AND MULTIPLE SCLEROSIS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 93, no. 6, 19 March 1996 (1996-03-19), pages 2499 - 2504, XP002013404, ISSN: 0027-8424
- [X] JEFFERY D R: "Relationship between disease activity and dose-response relationships with beta interferon therapies in the treatment of multiple sclerosis.", JOURNAL OF THE NEUROLOGICAL SCIENCES. 1 SEP 2000, vol. 178, no. 1, 1 September 2000 (2000-09-01), pages 2 - 9, XP002220791, ISSN: 0022-510X
- [A] MAURI CLAUDIA ET AL: "Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 6, no. 6, June 2000 (2000-06-01), pages 673 - 679, XP002157458, ISSN: 1078-8956
- [PX] COMABELLA MANUEL ET AL: "Interferon-beta treatment alters peripheral blood monocytes chemokine production in MS patients", JOURNAL OF NEUROIMMUNOLOGY, vol. 126, no. 1-2, May 2002 (2002-05-01), pages 205 - 212, XP002364117, ISSN: 0165-5728
- See references of WO 03045978A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03045978 A2 20030605; WO 03045978 A3 20030731; AU 2002346581 A1 20030610; AU 2002346581 A8 20030610; CA 2466931 A1 20030605; EP 1455812 A2 20040915; EP 1455812 A4 20060322; JP 2005510570 A 20050421
DOCDB simple family (application)
US 0238164 W 20021126; AU 2002346581 A 20021126; CA 2466931 A 20021126; EP 02784651 A 20021126; JP 2003547427 A 20021126