EP 1458396 A1 20040922 - 4-ARYLQUINAZOLINES AND USE THEREOF AS NHE-3 INHIBITORS
Title (en)
4-ARYLQUINAZOLINES AND USE THEREOF AS NHE-3 INHIBITORS
Title (de)
4-ARYL-CHINAZOLINE UND IHRE VERWENDUNG ALS NHE-3 INHIBITOREN
Title (fr)
4-ARYL-CHINAZOLINES ET UTILISATION EN TANT QU'INHIBITEURS DE NHE-3
Publication
Application
Priority
- DE 10163992 A 20011224
- EP 0213530 W 20021129
Abstract (en)
[origin: WO03055490A1] The invention relates to compounds of formula (I), where Ar = phenyl or naphthyl substituted by X and additionally substituted by R3 and R4, Y = (A), (B) or (C), X = H, NR6R7 or a saturated 5-7 membered ring with two N atoms, R1, R2, R3, R4 independently = H, A, OA, Hal, CF3, OH, NO2, NH2, NHA, NA2, NH-CO-A, NH-CO-Ph, SA, SO-A, SO2-A, SO2-Ph, CN, OCF3, CO-A, CO2H, CO2A, CO-NH2, CO-NHA, CO-NA2, SO2NH2, SO2NHA, SO2NA2 or unsubstituted or mono- or poly-substituted phenyl with A, OA, Hal or CF3, the salts, solvates and use thereof as NHE-3 inhibitors.
IPC 1-7
IPC 8 full level
C07D 239/84 (2006.01)
CPC (source: EP KR US)
A61P 3/00 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 7/00 (2017.12 - EP); A61P 7/02 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 13/00 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/02 (2017.12 - EP); A61P 31/00 (2017.12 - EP); A61P 31/04 (2017.12 - EP); A61P 33/00 (2017.12 - EP); C07D 239/84 (2013.01 - EP KR US); C07D 403/10 (2013.01 - KR)
Citation (search report)
See references of WO 03055490A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03055490 A1 20030710; AR 037973 A1 20041222; AU 2002356762 A1 20030715; BR 0215294 A 20050209; CA 2471524 A1 20030710; DE 10163992 A1 20030703; EP 1458396 A1 20040922; KR 20040066856 A 20040727; MX PA04006193 A 20041206; PL 369855 A1 20050502; US 2005020612 A1 20050127
DOCDB simple family (application)
EP 0213530 W 20021129; AR P020105062 A 20021220; AU 2002356762 A 20021129; BR 0215294 A 20021129; CA 2471524 A 20021129; DE 10163992 A 20011224; EP 02805750 A 20021129; KR 20047008400 A 20021129; MX PA04006193 A 20021129; PL 36985502 A 20021129; US 49997204 A 20040624