EP 1461460 A2 20040929 - METHODS FOR THE IDENTIFICATION OF INHIBITORS OF ASPARAGINE SYNTHASE, 5-AMINOLEVULINATE SYNTHASE, HISTIDINOL-PHOSPHATASE, 3-ISOPROPYLMALATE AND THREONINE SYNTHASE AS ANTIBIOTICS
Title (en)
METHODS FOR THE IDENTIFICATION OF INHIBITORS OF ASPARAGINE SYNTHASE, 5-AMINOLEVULINATE SYNTHASE, HISTIDINOL-PHOSPHATASE, 3-ISOPROPYLMALATE AND THREONINE SYNTHASE AS ANTIBIOTICS
Title (de)
VERFAHREN ZUR IDENTIFIZIERUNG VON INHIBITOREN DER ASPARAGINSYNTHASE, 5-AMINOLÄVULINAT-SYNTHASE, HISTIDINOL-PHOSPHATASE, 3-ISOPROPYLMALAT- UND THREONIN-SYNTHASE ALS ANTIBIOTIKA
Title (fr)
METHODES D'IDENTIFICATION D'INHIBITEURS DE L'ASPARAGINE SYNTHASE, DE LA 5-AMINOLEVULINATE SYNTHASE, DE L'HISTIDINOL PHOSPHATASE, DE LA 3-ISOPROPYLMALATE SYNTHASE ET DE LA THREONINE SYNTHASE EN TANT QU'ANTIBIOTIQUES
Publication
Application
Priority
- US 0239286 W 20021206
- US 702201 A 20011206
- US 1008401 A 20011206
- US 1022701 A 20011206
- US 1110601 A 20011207
- US 1299101 A 20011210
Abstract (en)
[origin: WO03050310A2] The present inventors have discovered that Asparagine Synthase, 5-Aminolevulinate synthase, histidinol-phosphatase, 3-Isopropylmalate dehydratase and Threonine synthase are essential for fungal pathogenicity. Specifically, the inhibition of Asparagine Synthase, 5-Aminolevulinate synthase, histidinol-phosphatase, 3-Isopropylmalate dehydratase or Threonine synthase gene expression in fungi results in no signs of successful infection or lesion. Thus, Asparagine Synthase, 5-Aminolevulinate synthase, histidinol-phosphatase, 3-Isopropylmalate dehydratase and Threonine synthase can be used as targets for the identification of antibiotics, preferably antifungals. Accordingly, the present inventio provides methods for the identification of compounds that inhibit Asparagine Synthase, 5-Aminolevulinate synthase, histidinol-hosphatase, 3-Isopropylmalate dehydratase or Threonine synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
IPC 1-7
C12Q 1/68; G01N 33/53; G01N 33/569; C12N 11/04; C12N 9/10; C12N 9/58; C12N 1/14; C12N 1/16; C12N 15/00; C07K 1/00; C07K 14/00
IPC 8 full level
C12N 15/09 (2006.01); C12N 9/00 (2006.01); C12N 9/10 (2006.01); C12N 9/16 (2006.01); C12N 9/88 (2006.01); C12Q 1/02 (2006.01); C12Q 1/18 (2006.01); C12Q 1/25 (2006.01); C12Q 1/42 (2006.01); C12Q 1/48 (2006.01); C12Q 1/527 (2006.01)
CPC (source: EP)
C12N 9/1029 (2013.01); C12N 9/16 (2013.01); C12N 9/88 (2013.01); C12N 9/93 (2013.01); C12Q 1/18 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR
DOCDB simple family (publication)
WO 03050310 A2 20030619; WO 03050310 A3 20031204; AU 2002363978 A1 20030623; CA 2469695 A1 20030619; EP 1461460 A2 20040929; EP 1461460 A4 20060705; JP 2005524390 A 20050818
DOCDB simple family (application)
US 0239286 W 20021206; AU 2002363978 A 20021206; CA 2469695 A 20021206; EP 02798496 A 20021206; JP 2003551331 A 20021206