EP 1463526 A2 20041006 - EARLY DETECTION OF MYCOBACTERIAL DISEASE USING PEPTIDES
Title (en)
EARLY DETECTION OF MYCOBACTERIAL DISEASE USING PEPTIDES
Title (de)
FRÜHERKENNUNG EINER MYCOBAKTERIELLEN ERKRANKUNG UNTER VERWENDUNG VON PEPTIDEN
Title (fr)
DETECTION PRECOCE DE MALADIES MYCOBACTERIENNES AU MOYEN DE PEPTIDES
Publication
Application
Priority
- US 0224297 W 20020802
- US 30918501 P 20010802
Abstract (en)
[origin: WO03012395A2] A number of protein and glycoprotein antigens secreted by <i>Mycobacterium tuberculosis</i> <i>(Mtb</i>) have been identified as "early"<i> Mtb</i> antigens on the basis early antibodies present in subjects infected with<i> Mtb</i> prior to the development of detectable clinical disease. Epitope-bearing peptide fragments of these early <i>Mtb</i> antigens, in particular of an 88 kDa secreted protein, GlcB (SEQ ID NO:106) and of <i>Mtb</i> antigen MPT51 (SEQ ID NO:107) have been identified. These peptides, variants thereof, peptide multimers thereof that include two or more repeats of one or more of the peptides, and fusion polypeptides that include early <i>Mtb</i> antigenic proteins, peptides or both, are useful in immunoassay methods for early, rapid detection of TB in a subject. Preferred immunoassays detect the antibodies in the subject's urine. Also provided are antigenic compositions, kits and methods to useful for detecting an early<i> Mtb</i> antibodies. The antigenic proteins and peptides are also used in vaccine compositions.
IPC 1-7
A61K 39/40; A61K 48/00; A61K 39/395; A61K 39/38; A61K 39/00; A61K 39/02; A61K 39/04; A61K 45/00; A61K 47/00
IPC 8 full level
C07K 14/35 (2006.01); G01N 33/569 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP US)
C07K 14/35 (2013.01 - EP); G01N 33/5695 (2013.01 - EP); A61K 39/00 (2013.01 - EP US); G01N 2469/20 (2013.01 - EP)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03012395 A2 20030213; WO 03012395 A3 20040722; AU 2002324578 B2 20090205; CN 1694725 A 20051109; EP 1463526 A2 20041006; EP 1463526 A4 20060830; ZA 200400843 B 20071128
DOCDB simple family (application)
US 0224297 W 20020802; AU 2002324578 A 20020802; CN 02819446 A 20020802; EP 02759228 A 20020802; ZA 200400843 A 20020802