EP 1465908 A2 20041013 - COMPOSITIONS AND METHODS FOR HYDROXYLATING EPOTHILONES
Title (en)
COMPOSITIONS AND METHODS FOR HYDROXYLATING EPOTHILONES
Title (de)
ZUSAMMENSETZUNGEN UND VERFAHREN ZUR HYDROXYLIERUNG VON EPOTHILONEN
Title (fr)
COMPOSITIONS ET METHODES D'HYDROXYLATION D'EPOTHILONES
Publication
Application
Priority
- US 0240359 W 20021217
- US 34427101 P 20011226
Abstract (en)
[origin: WO03057830A2] Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
IPC 1-7
C07H 21/02; C07H 21/04; C12N 9/04; C07K 1/00; C07K 14/00; C07K 17/00
IPC 8 full level
C12N 15/09 (2006.01); A61K 31/365 (2006.01); A61P 31/04 (2006.01); C07D 493/04 (2006.01); C07K 14/79 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/02 (2006.01); C12N 15/01 (2006.01); C12P 17/18 (2006.01)
CPC (source: EP)
A61P 31/04 (2017.12); C07K 14/79 (2013.01); C12N 9/0077 (2013.01); C12P 17/181 (2013.01); C07K 2299/00 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR
DOCDB simple family (publication)
WO 03057830 A2 20030717; WO 03057830 A3 20040805; AU 2002357872 A1 20030724; CA 2471874 A1 20030717; EP 1465908 A2 20041013; EP 1465908 A4 20051130; JP 2005514031 A 20050519; TW 200301697 A 20030716
DOCDB simple family (application)
US 0240359 W 20021217; AU 2002357872 A 20021217; CA 2471874 A 20021217; EP 02792416 A 20021217; JP 2003558132 A 20021217; TW 91136889 A 20021220