EP 1467748 A1 20041020 - STIMULATION OF BONE GROWTH AND CARTILAGE FORMATION WITH THROMBING PEPTIDE DERIVATIVES
Title (en)
STIMULATION OF BONE GROWTH AND CARTILAGE FORMATION WITH THROMBING PEPTIDE DERIVATIVES
Title (de)
STIMULIERUNG DES KNOCHENWACHSTUMS UND DER KNORPELGEWEBEBILDUNG MIT PEPTIDDERIVATEN VON THROMBIN
Title (fr)
STIMULATION DE LA CROISSANCE OSSEUSE ET DE LA FORMATION DU CARTILAGE AU MOYEN DE DERIVES PEPTIDIQUES DE LA THROMBINE
Publication
Application
Priority
US 0201451 W 20020117
Abstract (en)
[origin: WO03061690A1] Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction or cartilage repair. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site. Also disclosed is a method of stimulating the proliferation and expansion of chrondroxytes in vitro. The method comprises culturing chrondrocytes in the presence of a stimulating amount of an NPAR agonist.
IPC 1-7
IPC 8 full level
A61K 9/50 (2006.01); A61K 35/32 (2006.01); A61K 38/46 (2006.01); A61K 38/48 (2006.01); A61K 47/04 (2006.01); A61K 47/18 (2006.01); A61K 47/34 (2006.01); A61K 47/42 (2006.01); A61L 27/12 (2006.01); A61L 27/18 (2006.01); A61L 27/22 (2006.01); A61L 27/38 (2006.01); A61L 27/46 (2006.01); A61L 27/50 (2006.01); A61P 19/00 (2006.01); A61P 19/08 (2006.01); C12N 5/06 (2006.01); C12N 5/077 (2010.01); C12N 5/08 (2006.01); A61K 35/12 (2006.01)
CPC (source: EP)
A61K 38/4833 (2013.01); A61L 27/18 (2013.01); A61L 27/227 (2013.01); A61L 27/3817 (2013.01); A61L 27/3852 (2013.01); A61L 27/3895 (2013.01); A61P 19/00 (2017.12); A61P 19/08 (2017.12); C12N 5/0655 (2013.01); A61K 2035/128 (2013.01); C12N 2501/70 (2013.01); C12N 2533/40 (2013.01)
Citation (search report)
See references of WO 03061690A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 03061690 A1 20030731; AU 2002239965 B2 20070104; CA 2511257 A1 20030731; CN 1622826 A 20050601; EP 1467748 A1 20041020; JP 2005519067 A 20050630
DOCDB simple family (application)
US 0201451 W 20020117; AU 2002239965 A 20020117; CA 2511257 A 20020117; CN 02828568 A 20020117; EP 02705842 A 20020117; JP 2003561633 A 20020117