EP 1467987 A1 20041020 - PREPARATION OF LANSOPRAZOLE AND RELATED COMPOUNDS
Title (en)
PREPARATION OF LANSOPRAZOLE AND RELATED COMPOUNDS
Title (de)
HERSTELLUNG VON LANSOPRAZOL UND DERIVATEN
Title (fr)
PREPARATION DE LANSOPRAZOLE ET COMPOSES CONNEXES
Publication
Application
Priority
- US 0323588 W 20030728
- US 39868602 P 20020726
Abstract (en)
[origin: WO2004011455A1] The present invention provides a process for preparing lansoprazole (LNP) (I) and related compounds having a high yield and a low level of impurities by oxidation of corresponding sulfide (compound having formula (II)) with tert-butyl hydroperoxide (TBHP), catalyzed by a catalyst vanadium oxytrichloride in an organic solvent selected from the group consisting of a C1-C5 alkanol, decane, nonane, toluene and a mixture of the organic solvent and water, preferably in the presence of a base.
IPC 1-7
IPC 8 full level
C07D 401/12 (2006.01)
CPC (source: EP)
C07D 401/12 (2013.01)
Citation (search report)
See references of WO 2004011455A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004011455 A1 20040205; AU 2003268034 A1 20040216; EP 1467987 A1 20041020
DOCDB simple family (application)
US 0323588 W 20030728; AU 2003268034 A 20030728; EP 03748985 A 20030728