EP 1468007 A2 20041020 - PSEUDONUCLEOTIDE COMPRISING AN INTERCALATOR
Title (en)
PSEUDONUCLEOTIDE COMPRISING AN INTERCALATOR
Title (de)
PSEUDONUKLEOTIDE MIT INTERKALATOR
Title (fr)
PSEUDONUCLEOTIDE COMPRENANT UN INTERCALANT
Publication
Application
Priority
- DK 0200876 W 20021218
- DK PA200101897 A 20011218
- DK PA200101898 A 20011218
- DK PA200101899 A 20011218
- DK PA200101900 A 20011218
- DK PA200201576 A 20021014
- DK PA200201577 A 20021014
- DK PA200201578 A 20021014
- DK PA200201575 A 20021014
- US 36554502 P 20020320
Abstract (en)
[origin: WO03052134A2] The present invention relates to oligonucleotides or oligonucleotide analogues comprising at least two intercalator pseudonucleotides. Intercalator pseudonucleotides are capable of being incorporated into the backdone of a nucleic acid analogue and comprise an intercalator comprising at least one essentially flat conjugated system, which is capable of co-stacking with nucleobases of a nucleic acid. Furthermore, the invention relates to methods of detecting nucleic acids or nucleic acid analogues comprising a specific target sequence, methods of differentiating between a nucleic acid or nucleic acid analogue comprising a specific target sequence and a nucleic acid comprising a mutant sequence which differs from the target sequence by at least one nucleobase, and methods for detecting a target sequence and/or a mutant sequence, which offer from the target sequence by at least one nucleobase. In preferred embodiments of the invention said methods involve the use of oligonucleotides or oligonucleotide analogues comprising at least two intercalator pseudonucleotides.
IPC 1-7
IPC 8 full level
C07H 19/04 (2006.01); C07H 21/00 (2006.01); C12N 15/10 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12Q 1/68 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07H 19/04 (2013.01); C07H 21/00 (2013.01); C12N 15/1006 (2013.01); C12N 15/113 (2013.01); C12Q 1/6832 (2013.01); A61K 38/00 (2013.01); C12N 2310/13 (2013.01); C12N 2310/3181 (2013.01); C12N 2310/321 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/3511 (2013.01); C12N 2310/3517 (2013.01)
Citation (search report)
See references of WO 03051901A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR
DOCDB simple family (publication)
WO 03052134 A2 20030626; WO 03052134 A3 20040325; AU 2002358462 A1 20030630; AU 2002358462 A8 20030630; AU 2002358463 A1 20030630; AU 2002358463 A8 20030630; AU 2002358464 A1 20030630; AU 2002358464 B2 20060427; AU 2002361946 A1 20030630; AU 2002361946 A8 20030630; CN 1653079 A 20050810; CN 1653079 B 20100616; EP 1468007 A2 20041020; WO 03051901 A2 20030626; WO 03051901 A3 20031127; WO 03052132 A2 20030626; WO 03052132 A3 20031009; WO 03052133 A2 20030626; WO 03052133 A3 20031002
DOCDB simple family (application)
DK 0200877 W 20021218; AU 2002358462 A 20021218; AU 2002358463 A 20021218; AU 2002358464 A 20021218; AU 2002361946 A 20021218; CN 02828214 A 20021218; DK 0200874 W 20021218; DK 0200875 W 20021218; DK 0200876 W 20021218; EP 02792708 A 20021218