EP 1470237 A2 20041027 - MULTIFUNCTIONAL MONOCLONAL ANTIBODIES DIRECTED TO PEPTIDOGLYCAN OF GRAM-POSITIVE BACTERIA
Title (en)
MULTIFUNCTIONAL MONOCLONAL ANTIBODIES DIRECTED TO PEPTIDOGLYCAN OF GRAM-POSITIVE BACTERIA
Title (de)
GEGEN PEPTIDOGLYCAN GRAMPOSITIVER BAKTERIEN GERICHTETE MULTIFUNKTIONELLE MONOKLONALE ANTIKÖRPER
Title (fr)
ANTICORPS MONOCLONAUX MULTIFONCTIONNELS DIRIGES CONTRE LE PEPTIDOGLYCANE DE BACTERIES GRAM-POSITIF
Publication
Application
Priority
- US 0241032 W 20021223
- US 34344401 P 20011221
- US 34180601 P 20011221
Abstract (en)
[origin: WO03059259A2] The present invention encompasses protective monoclonal antibodies that bind to peptidoglycan of Gram-positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and block nasal colonization by Gram-positive bacteria in vivo. The invention also provides human, humanized and chimeric antibodies. The invention also sets forth the heavy chain and light chain variable regions of an antibody within the invention.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61P 31/04 (2006.01); C07K 16/12 (2006.01); C07K 19/00 (2006.01); C12N 5/10 (2006.01); C12P 21/08 (2006.01)
CPC (source: EP)
A61P 31/04 (2018.01); C07K 16/1267 (2013.01); C07K 16/1271 (2013.01); C07K 16/1275 (2013.01); C07K 16/1278 (2013.01); C07K 16/1296 (2013.01); A61K 39/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/56 (2013.01); C07K 2319/30 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR
DOCDB simple family (publication)
WO 03059259 A2 20030724; WO 03059259 A3 20040617; AU 2002364740 A1 20030730; AU 2009210372 A1 20090910; AU 2009210372 B2 20120726; CA 2469714 A1 20030724; EP 1470237 A2 20041027; EP 1470237 A4 20060201; JP 2005524624 A 20050818; JP 2010013454 A 20100121
DOCDB simple family (application)
US 0241032 W 20021223; AU 2002364740 A 20021223; AU 2009210372 A 20090817; CA 2469714 A 20021223; EP 02806494 A 20021223; JP 2003559424 A 20021223; JP 2009193403 A 20090824