EP 1472265 A2 20041103 - RNA INTERFERENCE MEDIATED INHIBITION OF POLYCOMB GROUP PROTEIN EZH2 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)
Title (en)
RNA INTERFERENCE MEDIATED INHIBITION OF POLYCOMB GROUP PROTEIN EZH2 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)
Title (de)
DURCH RNA-INTERFERENZ VERMITTELTE INHIBIERUNG DER GENEXPRESSION VON POLYCOMB GROUP PROTEIN EZH2 UNTER ANWENDUNG VON KURZER INTERFERIERENDER NUKLEINSÄURE (siNA)
Title (fr)
INHIBITION MEDIEE PAR INTERFERENCE D'ARN DE L'EXPRESSION DU GENE DE LA PROTEINE EZH2 DU GROUPE POLYCOMB A L'AIDE D'UN ACIDE NUCLEIQUE COURT INTERFERENT (SINA)
Publication
Application
Priority
- US 0304402 W 20030213
- US 35858002 P 20020220
- US 36312402 P 20020311
- US 38678202 P 20020606
- US 40678402 P 20020829
- US 40837802 P 20020905
- US 40929302 P 20020909
- US 42746702 P 20021119
- US 44012903 P 20030115
Abstract (en)
[origin: WO03070887A2] The present invention concerns methods and reagents useful in modulating polycomb group protein EZH2 gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid siNA, short interfering RNA siRNA, double-stranded RNA dsRNA, micro-RNA miRNA, and short hairpin RNA shRNA molecules capable of mediating RNA interference RNAi against polycomb group protein EZH2 gene expression and/or activity. The siNA molecules are useful in the treatment and diagnosis of prostate cancer and any other condition that responds to modulation of EZH2 expression or activity.
IPC 1-7
IPC 8 full level
A61K 47/48 (2006.01); C12N 15/113 (2010.01); C12N 15/115 (2010.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 47/54 (2017.07); C12N 15/1132 (2013.01); C12N 15/1137 (2013.01); C12N 15/115 (2013.01); C12Y 207/11013 (2013.01); C12Y 301/03048 (2013.01); A61K 38/00 (2013.01); C12N 2310/111 (2013.01); C12N 2310/12 (2013.01); C12N 2310/121 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/317 (2013.01); C12N 2310/318 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/332 (2013.01); C12N 2310/346 (2013.01); C12N 2310/53 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR
DOCDB simple family (publication)
WO 03070887 A2 20030828; WO 03070887 A3 20040129; AU 2003213054 A1 20030909; AU 2003213054 A8 20030909; EP 1472265 A2 20041103; EP 1472265 A4 20050615
DOCDB simple family (application)
US 0304402 W 20030213; AU 2003213054 A 20030213; EP 03709096 A 20030213