EP 1475092 A1 20041110 - Blockers of the quorum sensing system of Gram-negative bacteria

Title (en)

Blockers of the quorum sensing system of Gram-negative bacteria

Title (de)

Hemmer des "quorum sensing" Mechanismus von Gramnegativen Bakterien

Title (fr)

Bloqueurs du system de detection de quorum des bacteries Gram-negatives

Publication

EP 1475092 A1 20041110 (EN)

Application

EP 03010185 A 20030506

Priority

EP 03010185 A 20030506

Abstract (en)

The present invention relates to the use of compounds of the general Formula (XIII): <CHEM> wherein A<7> is C=O, C=S, SO2, CH-OR<13>, C=NR<12>, or CH2-CHOR<13>; A<8> is C(R<14>)2, O, S, or NR<12>; A<9> is C=O, C=S, SO2, CH-OR<13>, C=NR<12>, or CH2-CHOR<13>; m is 0, or 1 q is 0, or 1 r is 0, or 1 R<12> is H, CH3, CH2-CH3, OCH3, OCH2-CH3, OH, or SH; R<13> is H, CH3, or CH2-CH3; R<14> is H, alkyl, alkoxy, OH, or SH; as selective inhibitors of bacterial pathogens. In particular the invention refers to a family of compounds that block the quorum sensing system of Gram-negative bacteria, a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of microbial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens.

IPC 1-7

A61K 31/415; A61P 31/04; C07D 231/40; C07D 333/38; C07D 275/02; C07D 277/46; C07D 277/54; C07D 261/14; C07D 263/48; C07D 307/68; A61K 31/381; A61K 31/42; A61K 31/421

IPC 8 full level

A61P 31/04 (2006.01); C07D 231/12 (2006.01); C07D 231/40 (2006.01); C07D 261/14 (2006.01); C07D 263/48 (2006.01); C07D 275/03 (2006.01); C07D 277/46 (2006.01); C07D 277/54 (2006.01); C07D 307/68 (2006.01); C07D 333/38 (2006.01); C07D 275/02 (2006.01)

CPC (source: EP)

A61P 31/04 (2017.12); C07D 231/40 (2013.01); C07D 261/14 (2013.01); C07D 263/48 (2013.01); C07D 275/03 (2013.01); C07D 277/46 (2013.01); C07D 277/54 (2013.01); C07D 307/68 (2013.01); C07D 333/38 (2013.01)

Citation (search report)

[X] GB 2331299 A 19990519 - EASTMAN KODAK CO [US]
[X] EP 0525686 A1 19930203 - LUITPOLD PHARMA GMBH [DE]
[X] JP H03232849 A 19911016 - DAICEL CHEM
[X] EP 0540472 A1 19930505 - CIBA GEIGY AG [CH]
[X] FR 1439334 A 19660520 - KODAK PATHE
[X] WO 9524403 A1 19950914 - ZENECA LTD [GB], et al
[E] WO 03039529 A1 20030515 - 4SC A G [DE], et al
[E] WO 03039549 A2 20030515 - 4SC AG [DE], et al
[A] WO 9857618 A1 19981223 - UNIV MONTANA RES DEV INST [US], et al
[A] US 6395282 B1 20020528 - KENDE ANDREW S [US], et al
[A] WO 9927786 A1 19990610 - UNIV NOTTINGHAM [GB], et al
[X] PAK, CHWANG SIEK; YANG, HEUI CHEOL; CHOI, EUN BOK: "Aminolysis of 5-acyl-2,2-dimethyl-1,3-dioxan-4,6-diones (acyl Meldrum'sacids) as a versatile method for the synthesis of .beta.-oxo carboxamides", SYNTHESIS (1992), (12), 1213-14, XP001154580
[X] PATENT ABSTRACTS OF JAPAN vol. 009, no. 079 (P - 347) 9 April 1985 (1985-04-09)
[DA] SMITH KRISTINA M ET AL: "Induction and Inhibition of Pseudomonas aeruginosa Quorum Sensing by Synthetic Autoinducer Analogs.", CHEMISTRY & BIOLOGY. ENGLAND JAN 2003, vol. 10, no. 1, January 2003 (2003-01-01), pages 81 - 89, XP002254860, ISSN: 1074-5521

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

DOCDB simple family (publication)

EP 1475092 A1 20041110; CA 2526904 A1 20041118; EP 1622890 A2 20060208; WO 2004099175 A2 20041118; WO 2004099175 A3 20041229

DOCDB simple family (application)

EP 03010185 A 20030506; CA 2526904 A 20040506; EP 04731333 A 20040506; EP 2004004850 W 20040506