EP 1478730 A4 20060125 - RNA INTERFERENCE MEDIATED INHIBITION OF TNF AND TNF RECEPTOR SUPERFAMILY GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
Title (en)
RNA INTERFERENCE MEDIATED INHIBITION OF TNF AND TNF RECEPTOR SUPERFAMILY GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
Title (de)
RNA-INTERFERENZ-VERMITTELTE HEMMUNG DER EXPRESSION DER GENE FÜR DIE TNF- UND TNF-REZEPTOR-SUPERFAMILIEN UNTER VERWENDUNG VON siNA (SHORT INTERFERING NUCLEIC ACID)
Title (fr)
INHIBITION, INDUITE PAR ARN D'INTERFERENCE, DE L'EXPRESSION GENIQUE DE LA SUPERFAMILLE TFN ET DE LA SUPERFAMILLE DES RECEPTEURS DE TFN A L'AIDE D'UN ACIDE NUCLEIQUE A INTERFERENCE COURTE (SINA)
Publication
Application
Priority
- US 0304741 W 20030220
- US 35858002 P 20020220
- US 36312402 P 20020311
- US 38678202 P 20020606
- US 40678402 P 20020829
- US 40837802 P 20020905
- US 40929302 P 20020909
- US 42935902 P 20021126
- US 44012903 P 20030115
Abstract (en)
[origin: WO03070897A2] The present invention concerns methods and reagents useful in modulating TNF superfamily and TNF receptor superfamily gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against TNF superfamily and TNF receptor superfamily gene expression and/or activity. The small nucleic acid molecules are useful in the treatment of septic shock, rheumatoid arthritis, HIV and AIDS, psoriasis, inflammatory or autoimmune disorders and any other disease or condition that responds to modulation of TNF and/or TNF receptor expression or activity.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 48/00 (2006.01); A61P 9/00 (2006.01); A61P 17/06 (2006.01); A61P 29/00 (2006.01); A61P 31/04 (2006.01); A61P 31/18 (2006.01); A61P 37/06 (2006.01); A61P 43/00 (2006.01); C12N 15/113 (2010.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 9/00 (2017.12); A61P 17/06 (2017.12); A61P 29/00 (2017.12); A61P 31/04 (2017.12); A61P 31/18 (2017.12); A61P 37/06 (2017.12); A61P 43/00 (2017.12); C12N 15/1136 (2013.01); C12N 15/1138 (2013.01); C12N 2310/111 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/317 (2013.01); C12N 2310/318 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/332 (2013.01); C12N 2310/53 (2013.01)
Citation (search report)
- [Y] WO 9927086 A1 19990603 - BRAX GENOMICS LTD [GB], et al
- [Y] WO 9410301 A1 19940511 - GENE SHEARS PTY LTD [AU], et al
- [Y] WO 0000504 A1 20000106 - ISIS PHARMACEUTICALS INC [US], et al
- [Y] WO 0044895 A1 20000803 - KREUTZER ROLAND [DE], et al
- [PY] WO 0244321 A2 20020606 - MAX PLANCK GESELLSCHAFT [DE], et al & DATABASE NCBI 31 October 2000 (2000-10-31), XP002342405, retrieved from NCBI Database accession no. NM_000594
- [Y] ELBASHIR S M ET AL: "Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 20, no. 23, 3 December 2001 (2001-12-03), pages 6877 - 6888, XP002225998, ISSN: 0261-4189
- [Y] DAVIS J M ET AL: "STRUCTURE OF HUMAN TUMOR NECROSIS FACTOR ALPHA DERIVED FROM RECOMBINANT DNA", BIOCHEMISTRY, vol. 26, no. 5, 1987, pages 1322 - 1326, XP002340302, ISSN: 0006-2960
- See references of WO 03070897A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR
DOCDB simple family (publication)
WO 03070897 A2 20030828; WO 03070897 A3 20040910; AU 2003217550 A1 20030909; CA 2477014 A1 20030828; EP 1478730 A2 20041124; EP 1478730 A4 20060125; JP 2005517433 A 20050616
DOCDB simple family (application)
US 0304741 W 20030220; AU 2003217550 A 20030220; CA 2477014 A 20030220; EP 03713502 A 20030220; JP 2003569790 A 20030220