EP 1478771 A2 20041124 - METHODS FOR CHARACTERIZATION OF NUCLEIC ACID MOLECULES
Title (en)
METHODS FOR CHARACTERIZATION OF NUCLEIC ACID MOLECULES
Title (de)
VERFAHREN ZUR CHARAKTERISIERUNG VON NUKLEINSÄUREMOLEKÜLEN
Title (fr)
PROCEDES DE CARACTERISATION DE MOLECULES D'ACIDE NUCLEIQUE
Publication
Application
Priority
- US 0219766 W 20020621
- US 29987001 P 20010621
Abstract (en)
[origin: WO03000920A2] To probe the characteristics of a target nucleic acid molecule or a population of target nucleic acid molecules, a local cross-sectional area, local charge, or local chemistry of a molecule is modified. The modified nucleic acid is contacted with a substrate that includes a detector that is responsive to the modification in the local cross-sectional area, local charge, or local chemistry of the nucleic acid molecule. The modified nucleic acid molecule traverses a defined and preferably molecular dimensioned volume on the substrate so that nucleotides of the modified nucleic acid molecule interact with the detector in sequential order, whereby data correlating with the cross-sectional area, local charge, or local chemistry of the nucleic acid molecule are obtained. The nucleic acid molecule may be modified in a number of locations along the molecule's length. Because the individual nucleotides of the nucleic acid molecule interact with the detector in sequential order, information regarding the location and composition of a plurality of modified sites along a single molecule can be obtained.
IPC 1-7
IPC 8 full level
C12Q 1/68 (2006.01); C12Q 1/6825 (2018.01); C12Q 1/6827 (2018.01); G07F 17/32 (2006.01); H04N 7/18 (2006.01); C12Q 1/6816 (2018.01)
CPC (source: EP)
C12Q 1/6825 (2013.01); C12Q 1/6827 (2013.01); G01N 33/48721 (2013.01); H04N 7/18 (2013.01); C12Q 1/6816 (2013.01)
C-Set (source: EP)
Designated contracting state (EPC)
DE FR GB
DOCDB simple family (publication)
WO 03000920 A2 20030103; WO 03000920 A3 20040923; WO 03000920 A9 20030320; AU 2002318386 A1 20030108; EP 1478771 A2 20041124; EP 1478771 A4 20050615
DOCDB simple family (application)
US 0219766 W 20020621; AU 2002318386 A 20020621; EP 02747942 A 20020621