EP 1479693 A1 20041124 - EGF/EGFR COMPLEX
Title (en)
EGF/EGFR COMPLEX
Title (de)
EGF/EGFR-KOMPLEX
Title (fr)
COMPLEXE EGF/EGFR
Publication
Application
Priority
- JP 0209332 W 20020912
- JP 2002028780 A 20020205
Abstract (en)
The present invention relates to a crystal of a complex of an epidermal growth factor (EGF) and an epidermal growth factor receptor (EGFR), a crystal of a complex of EGFR and a substance regulating EGFR activity, structure coordinates of these crystals, a method for screening for the substance regulating EGFR activity, a method for designing the substance regulating EGFR activity, a method for designing an EGFR variant or an EGF variant, a method for producing an EGFR variant or an EGF variant and an EGF variant or an EGFR variant obtainable by such method, a method for designing an epitope using the structure coordinates of the EGF-EGFR complex, a method for producing an anti-EGFR antibody or an anti-EGF antibody and an antibody obtainable by such method, a polypeptide or a salt thereof comprising a region that forms an EGFR dimerization site, and the like. <IMAGE>
IPC 1-7
C07K 14/485; C07K 14/71; G01N 33/566; C07K 16/22; C07K 16/28
IPC 8 full level
C07K 14/485 (2006.01); C07K 14/71 (2006.01); C07K 16/22 (2006.01); C07K 16/28 (2006.01)
CPC (source: EP US)
C07K 14/485 (2013.01 - EP US); C07K 14/71 (2013.01 - EP US); C07K 16/22 (2013.01 - EP US); C07K 16/2863 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US); C07K 2299/00 (2013.01 - EP US); C07K 2317/32 (2013.01 - EP US); C07K 2317/34 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
EP 1479693 A1 20041124; EP 1479693 A4 20050727; AU 2002338064 A1 20030902; CA 2476006 A1 20030814; JP WO2003066677 A1 20050526; US 2007032637 A1 20070208; US 7514240 B2 20090407; WO 03066677 A1 20030814
DOCDB simple family (application)
EP 02772848 A 20020912; AU 2002338064 A 20020912; CA 2476006 A 20020912; JP 0209332 W 20020912; JP 2003566048 A 20020912; US 50348604 A 20040805