EP 1480953 B2 20100818 - PROCESS FOR PREPARING ARIPIPRAZOLE
Title (en)
PROCESS FOR PREPARING ARIPIPRAZOLE
Title (de)
VERFAHREN ZUR HERSTELLUNG VON ARIPIPRAZOLE
Title (fr)
PROCEDE DE PREPARATION D'ARIPIPRAZOLE
Publication
Application
Priority
- JP 0316256 W 20031218
- JP 2003002996 A 20030109
Abstract (en)
[origin: US2004192915A1] The present invention provides a process for preparing aripiprazole in a high purity and a high yield. According to the process of the present invention, aripiprazole is prepared by the reaction of a carbostyril compound represented by general formula (2): (wherein X is halogen atom, lower alkanesulfonyloxy group, arylsulfonyloxy group or an aralkylsulfonyloxy group), with a piperazine compound represented by formula (3): and/or a salt thereof in water, in the presence of 0.5 to 10 mol of an inorganic basic compound, per mol of the carbostyril compound (2).
IPC 8 full level
C07D 215/22 (2006.01); C07D 215/227 (2006.01)
CPC (source: EP KR US)
A61P 25/18 (2018.01 - EP); C07D 215/227 (2013.01 - EP US); C07D 401/12 (2013.01 - KR); C07D 403/12 (2013.01 - KR)
Citation (opposition)
Opponent :
- EP 1330249 A1 20030730 - OTSUKA PHARMA CO LTD [JP]
- WO 02090351 A1 20021114 - OTSUKA PHARMA CO LTD [JP], et al
- DE 3034237 A1 19810416 - OTSUKA PHARMA CO LTD [JP]
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
US 2004192915 A1 20040930; US 6995264 B2 20060207; AR 042702 A1 20050629; AT E308524 T1 20051115; AU 2003288755 A1 20040810; AU 2003288755 B2 20050825; AU 2003288755 C1 20150219; BR 0305500 A 20041103; BR PI0305500 B1 20180123; CA 2458929 A1 20040709; CA 2458929 C 20090908; CA 2676216 A1 20040709; CN 1263742 C 20060712; CN 1590377 A 20050309; DE 60302139 D1 20051208; DE 60302139 T2 20060720; DE 60302139 T3 20110224; DK 1480953 T3 20051219; DK 1480953 T4 20101115; EG 23557 A 20060605; EP 1480953 A1 20041201; EP 1480953 B1 20051102; EP 1480953 B2 20100818; ES 2250919 T3 20060416; ES 2250919 T5 20101203; HK 1073110 A1 20050923; JP 2012031203 A 20120216; JP 2014148511 A 20140821; JP 5797090 B2 20151021; KR 100583667 B1 20060526; KR 20040093655 A 20041106; MX PA04002519 A 20050404; MY 129831 A 20070531; SI 1480953 T1 20060430; SI 1480953 T2 20101231; TW 200418840 A 20041001; TW I258470 B 20060721; WO 2004063162 A1 20040729
DOCDB simple family (application)
US 75249004 A 20040108; AR P040100006 A 20040105; AT 03780889 T 20031218; AU 2003288755 A 20031218; BR 0305500 A 20031218; BR PI0305500 A 20031218; CA 2458929 A 20031218; CA 2676216 A 20031218; CN 200410002064 A 20040109; DE 60302139 T 20031218; DK 03780889 T 20031218; EG 2004010004 A 20040105; EP 03780889 A 20031218; ES 03780889 T 20031218; HK 05105804 A 20050711; JP 0316256 W 20031218; JP 2011241871 A 20111104; JP 2014043786 A 20140306; KR 20047003990 A 20031218; MX PA04002519 A 20031218; MY PI20040043 A 20040108; SI 200330153 T 20031218; TW 92135997 A 20031218