EP 1481967 A4 20070131 - PROCESS FOR THE PREPARATION OF BIARYL COMPOUNDS
Title (en)
PROCESS FOR THE PREPARATION OF BIARYL COMPOUNDS
Title (de)
VERFAHREN ZUR HERSTELLUNG VON BIARYLVERBINDUNGEN
Title (fr)
PROCEDE DE PREPARATION DE COMPOSES BIARYLE
Publication
Application
Priority
- JP 0302460 W 20030304
- JP 2002058624 A 20020305
- JP 2002073833 A 20020318
Abstract (en)
[origin: US2004158093A1] A process for preparing an optically active biaryl compound the formula (4): wherein R*, R<2>, R<3>, n1, n2 and * are as defined hereinafter, which comprises reacting an aromatic sulfonic acid ester compound of the formula (1): wherein R<1 >is a substituted or unsubstituted alkyl or aryl group, R<2 >is the same or different and represents a fluorine atom, a cyano group, a nitro group, a substituted or unsubstituted linear or branched alkyl group, etc., R* is the same or different and represents a substituent having at least one asymmetric carbon, or the substituents on the adjacent carbon atoms of the benzene ring may be bound each other and taken together with the benzene ring to form a fused polycyclic aromatic ring, and provided that R<1 >is not a trifluoromethyl group, a nonafluorobutyl group or a pentafluorophenyl group, with an organic boron compound of the formula (2): wherein R<3 >is a substituted or unsubstituted aryl or heteroaryl group, and Q<1 >and Q<2 >are the same or different and each is a hydroxyl group, an alkoxy group having 1 to 4 carbon atoms, etc., at 70° C. or below in the presence of a nickel catalyst and a base.
IPC 1-7
C07C 269/06; C07C 271/22; C07C 309/66; C07C 309/73; C07C 303/28; C07B 61/00; C07B 53/00; C07D 333/24
IPC 8 full level
C07B 37/04 (2006.01); C07C 269/06 (2006.01); C07C 271/22 (2006.01); C07D 333/24 (2006.01)
CPC (source: EP US)
C07B 37/04 (2013.01 - EP US); C07C 269/06 (2013.01 - EP US); C07C 271/22 (2013.01 - EP US); C07D 333/24 (2013.01 - EP US); C07B 2200/07 (2013.01 - EP US)
Citation (search report)
- [X] WO 9926921 A1 19990603 - MERCK & CO INC [US], et al
- [X] EP 1043309 A1 20001011 - LG CHEMICAL LTD [KR]
- [X] WO 9955324 A1 19991104 - SMITHKLINE BEECHAM CORP [US], et al
- [X] WO 0196304 A1 20011220 - LILLY CO ELI [US], et al
- [Y] WO 9936393 A1 19990722 - TANABE SEIYAKU CO [JP], et al
- [X] P. KARRER ET AL.: "Überführung optisch aktiver alpha-Aminocarbonsäuren in optisch aktive Amine mit gleichen Kohlenstoffskelett", HELV. CHIM. ACTA, vol. 34, 1951, pages 2202 - 2210, XP002412039
- [Y] PERCEC V ET AL: "Aryl mesylates in metal catalyzed homocoupling and cross-coupling reactions. 2", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 60, no. 4, 1995, pages 1060 - 1065, XP002969965, ISSN: 0022-3263
- See references of WO 03074478A1
Designated contracting state (EPC)
CH DE FR GB IT LI
DOCDB simple family (publication)
US 2004158093 A1 20040812; US 7271280 B2 20070918; DE 60336986 D1 20110616; EP 1481967 A1 20041201; EP 1481967 A4 20070131; EP 1481967 B1 20110504; EP 2161254 A1 20100310; EP 2161254 B1 20140813; US 2007270603 A1 20071122; US 7714157 B2 20100511; WO 03074478 A1 20030912
DOCDB simple family (application)
US 77449804 A 20040210; DE 60336986 T 20030304; EP 03743573 A 20030304; EP 09015776 A 20030304; JP 0302460 W 20030304; US 87882007 A 20070727