Global Patent Index - EP 1482945 A1

EP 1482945 A1 2004-12-08 - CRYSTALLINE FORMS OF QUETIAPINE HEMIFUMARATE

Title (en)

CRYSTALLINE FORMS OF QUETIAPINE HEMIFUMARATE

Title (de)

KRIYSTALLINE FORMEN VON QUETIAPIN-HEMIFUMARAT

Title (fr)

FORMES CRISTALLINES D'HEMIFUMARATE DE QUETIAPINE

Publication

EP 1482945 A1 (EN)

Application

EP 03721434 A

Priority

  • US 0308898 W
  • US 36591302 P
  • US 44358503 P

Abstract (en)

[origin: WO03080065A1] The present invention relates to novel crystalline forms of quetiapine hemifumarate (I), denominated quetiapine hemifuramate form II and quetiapine hemifuramate form III. These novel crystalline forms of quetiapine hemifuramate have been characterized by methods including x-ray powder diffraction (XRD), Fourier transform IR spectroscopy (FTIR), differential scanning calorimetry (DSC), and thermal gravimetric analysis (TGA). Methods for preparation of the novel crystalline quetiapine hemifuramate form II as its chloroform solvate and its dichloromethane solvate, form III as its chloroform solvate, and form I are provided.

IPC 1-7 (main, further and additional classification)

A61K 31/55; A61P 25/18; C07D 281/16

IPC 8 full level (invention and additional information)

A61P 25/18 (2006.01); C07D 281/16 (2006.01)

CPC (invention and additional information)

C07D 281/16 (2013.01)

Citation (search report)

See references of WO 03080065A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

EPO simple patent family

WO 03080065 A1 20031002; AU 2003235435 A1 20031008; CA 2479668 A1 20031002; EP 1482945 A1 20041208; EP 2000141 A1 20081210; IL 164155 A 20120329; IL 164155 D0 20051218; JP 2006513131 A 20060420; JP 4414237 B2 20100210; US 2003216376 A1 20031120; US 2010016579 A1 20100121

INPADOC legal status


2009-09-02 [18R] REFUSED

- Effective date: 20090311

2008-05-21 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: LIFSHITZ-LIRON, REVITAL

2008-05-21 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: KOVALEVSKI-ISHAI, ETI

2008-05-21 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: DILLER, DOV

2008-05-21 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: WIZEL, SHLOMIT

2008-05-21 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: LIDOR-HADAS, RAMI

2006-12-20 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20050808

2004-12-08 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20040902

2004-12-08 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

2004-12-08 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Countries: AL LT LV MK