EP 1485071 A2 20041215 - COMPRESSED TABLETS COMPRISING MICROCAPSULES WITH MODIFIED RELEASE
Title (en)
COMPRESSED TABLETS COMPRISING MICROCAPSULES WITH MODIFIED RELEASE
Title (de)
KOMPRIMIERTE TABLETTEN MIT MIKROKAPSELN MIT MODIFIZIERTER FREISETZUNG
Title (fr)
COMPRIMES A BASE DE MICROCAPSULES A LIBERATION MODIFIEE
Publication
Application
Priority
- FR 0300827 W 20030314
- FR 0203336 A 20020318
Abstract (en)
[origin: WO03077888A2] The aim of the invention is to provide a multi(micro)particulate compressed tablet which comprises a non-mechanically-deformable active principle core (crystal, granule) and which allows the prolonged in vivo release of said active principle, without the release profile being modified by the compression (microparticles not specifically formulated for the compression). Said aim is achieved with the inventive compressed tablet comprising reservoir-type microcapsules with prolonged release of the active principle. According to the invention, each of said microcapsules is formed by a non-deformable core comprising the active principle and covered by at least one coating film which controls the prolonged in vivo release of the active principle. Moreover, each microcapsule has a particle size distribution of between 50 and 1,000 ñm and comprises at least one outer overcoating envelope which is based on at least one deformable organic component having a melting temperature of between 40 DEG C and 120 DEG C (polyethylene glycol). The invention also relates to the overcoated microcapsules which are resistant to compression.
IPC 1-7
IPC 8 full level
A61K 9/20 (2006.01); A61K 9/26 (2006.01); A61K 9/50 (2006.01); A61K 9/52 (2006.01); A61K 9/56 (2006.01); A61K 31/155 (2006.01); A61K 31/522 (2006.01); A61K 47/04 (2006.01); A61K 47/12 (2006.01); A61K 47/14 (2006.01); A61K 47/32 (2006.01); A61K 47/38 (2006.01); A61K 47/44 (2006.01)
CPC (source: EP KR US)
A61K 9/20 (2013.01 - KR); A61K 9/2081 (2013.01 - EP US); A61K 9/50 (2013.01 - KR); A61K 9/5073 (2013.01 - EP US)
Citation (search report)
See references of WO 03077888A2
Citation (examination)
- US 5674529 A 19971007 - MARDER HERMAN [US], et al
- EP 0477135 A1 19920325 - WARNER LAMBERT CO [US]
- EP 0601508 A2 19940615 - RECORDATI CHEM PHARM [CH]
- WO 02072072 A2 20020919 - ETHYPHARM LAB PROD ETHIQUES [FR], et al
- GB 1021178 A 19660302 - SMITH KLINE FRENCH LAB
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 03077888 A2 20030925; WO 03077888 A3 20040415; AU 2003242818 A1 20030929; AU 2003242818 B2 20081218; BR 0308487 A 20050118; CA 2479057 A1 20030925; CA 2479057 C 20120207; CN 1642530 A 20050720; EP 1485071 A2 20041215; FR 2837100 A1 20030919; FR 2837100 B1 20040723; IL 163813 A0 20051218; IL 163813 A 20100630; JP 2005527522 A 20050915; KR 20040105773 A 20041216; MX PA04009010 A 20041126; US 2005266078 A1 20051201; US 8507003 B2 20130813; ZA 200408412 B 20060830
DOCDB simple family (application)
FR 0300827 W 20030314; AU 2003242818 A 20030314; BR 0308487 A 20030314; CA 2479057 A 20030314; CN 03806302 A 20030314; EP 03744400 A 20030314; FR 0203336 A 20020318; IL 16381303 A 20030314; IL 16381304 A 20040830; JP 2003575941 A 20030314; KR 20047014579 A 20030314; MX PA04009010 A 20030314; US 50788603 A 20030314; ZA 200408412 A 20041018