EP 1485497 A2 20041215 - Ricin derivatives and vaccines based thereon
Title (en)
Ricin derivatives and vaccines based thereon
Title (de)
Derivate von Rizin und darauf basierte Impfstoffe
Title (fr)
Dérivatives de ricin et vaccin basent sur celles-ci
Publication
Application
Priority
US 0205732 W 20020227
Abstract (en)
[origin: WO03072018A2] Disclosed herein are polypeptides and variants thereof comprising a polypeptide sequence having substantial identity to ricin A chain (RTA0 that lack detectable N-glycosidase-rRNA activity or exhibit reduced N-glycosidase-rRNA activity as compared to controls and methods of making and using thereof. The polypeptides and variants have a greater solubility in aqueous solutions of physiological pH and ionic strength than RTA and also retain the integretiy of the neutralizing immunological epitope of wild type RTA. Also disclosed are immunogenic compositions that may be used to immunize a subject against ricin intoxication. Methods of immunizing against, treating, and preventing ricin intoxication are disclosed.
IPC 1-7
C12Q 1/00; C12N 9/00; C12N 9/24; C12N 9/26; C12N 9/38; C07H 21/04; A61K 38/43
IPC 8 full level
C12N 9/00 (2006.01); A61K 38/43 (2006.01); A61K 38/47 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); C07K 14/415 (2006.01); C12N 9/24 (2006.01); C12N 9/26 (2006.01); C12N 9/38 (2006.01); C12N 15/52 (2006.01)
CPC (source: EP)
C07K 14/415 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 03072018 A2 20030904; WO 03072018 A3 20040129; AU 2002252102 A1 20030909; CA 2477094 A1 20030904; EP 1485497 A2 20041215; EP 1485497 A4 20050727
DOCDB simple family (application)
US 0205732 W 20020227; AU 2002252102 A 20020227; CA 2477094 A 20020227; EP 02721157 A 20020227