EP 1487782 A1 20041222 - PROCESS FOR PREPARING NATEGLINIDE AND INTERMEDIATES THEREOF
Title (en)
PROCESS FOR PREPARING NATEGLINIDE AND INTERMEDIATES THEREOF
Title (de)
VERFAHREN ZUR HERSTELLUNG VON NATEGLINID SOWIE ZWISCHENPRODUKTE
Title (fr)
PROCEDE DE PREPARATION DU NATEGLINIDE ET INTERMEDIAIRES
Publication
Application
Priority
- US 0321238 W 20030703
- US 39349502 P 20020703
- US 39690402 P 20020718
- US 41362202 P 20020925
- US 41419902 P 20020926
- US 42375002 P 20021105
- US 43209302 P 20021210
- US 43296202 P 20021212
- US 44210903 P 20030123
- US 44979103 P 20030224
- US 47901603 P 20030616
Abstract (en)
[origin: WO2004005240A1] Provided is a process for preparation of an intermediate in the synthesis of nateglinide. Trans-4-isopropylcyclohexane acid chloride is formed by reacting 4-isopropylcyclohexanecarboxyl acid with thionyl chloride in the presence of an effective amount of an organic amide. Also provided are processes for preparation of nateglinide by acylation of a suitable salt of D-phenylalanine with trans-4-isopropylcyclohexane acid chloride in both a single and a two phase system, and in water free of a co-solvent.
IPC 1-7
C07C 231/02; C07C 231/24; C07C 233/63; C07C 51/60; C07C 61/08
IPC 8 full level
A61K 31/16 (2006.01); A61K 31/198 (2006.01); C07C 51/60 (2006.01); C07C 231/02 (2006.01); C07C 231/24 (2006.01); C07C 233/63 (2006.01)
CPC (source: EP)
A61K 31/16 (2013.01); A61K 31/198 (2013.01); C07C 51/60 (2013.01); C07C 231/02 (2013.01); C07C 231/24 (2013.01); C07B 2200/13 (2013.01); C07C 2601/14 (2017.04)
Citation (search report)
See references of WO 2004005240A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004005240 A1 20040115; AU 2003256454 A1 20040123; CN 100384813 C 20080430; CN 1671649 A 20050921; EP 1487782 A1 20041222; IL 166087 A0 20060115
DOCDB simple family (application)
US 0321238 W 20030703; AU 2003256454 A 20030703; CN 03817439 A 20030703; EP 03763310 A 20030703; IL 16608705 A 20050102