Global Patent Index - EP 1487782 A1

EP 1487782 A1 2004-12-22 - PROCESS FOR PREPARING NATEGLINIDE AND INTERMEDIATES THEREOF

Title (en)

PROCESS FOR PREPARING NATEGLINIDE AND INTERMEDIATES THEREOF

Title (de)

VERFAHREN ZUR HERSTELLUNG VON NATEGLINID SOWIE ZWISCHENPRODUKTE

Title (fr)

PROCEDE DE PREPARATION DU NATEGLINIDE ET INTERMEDIAIRES

Publication

EP 1487782 A1 (EN)

Application

EP 03763310 A

Priority

  • US 0321238 W
  • US 39349502 P
  • US 39690402 P
  • US 41362202 P
  • US 41419902 P
  • US 42375002 P
  • US 43209302 P
  • US 43296202 P
  • US 44210903 P
  • US 44979103 P
  • US 47901603 P

Abstract (en)

[origin: WO2004005240A1] Provided is a process for preparation of an intermediate in the synthesis of nateglinide. Trans-4-isopropylcyclohexane acid chloride is formed by reacting 4-isopropylcyclohexanecarboxyl acid with thionyl chloride in the presence of an effective amount of an organic amide. Also provided are processes for preparation of nateglinide by acylation of a suitable salt of D-phenylalanine with trans-4-isopropylcyclohexane acid chloride in both a single and a two phase system, and in water free of a co-solvent.

IPC 1-7 (main, further and additional classification)

C07C 231/02; C07C 51/60; C07C 61/08; C07C 231/24; C07C 233/63

IPC 8 full level (invention and additional information)

A61K 31/16 (2006.01); A61K 31/198 (2006.01); C07C 51/60 (2006.01); C07C 231/02 (2006.01); C07C 231/24 (2006.01); C07C 233/63 (2006.01)

CPC (invention and additional information)

C07C 231/24 (2013.01); A61K 31/16 (2013.01); A61K 31/198 (2013.01); C07C 51/60 (2013.01); C07C 231/02 (2013.01); C07B 2200/13 (2013.01); C07C 2601/14 (2017.05)

Combination set (CPC)

  1. C07C 51/60 + C07C 61/08
  2. C07C 231/02 + C07C 233/63
  3. C07C 231/24 + C07C 233/63

Citation (search report)

See references of WO 2004005240A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

EPO simple patent family

WO 2004005240 A1 20040115; AU 2003256454 A1 20040123; CN 100384813 C 20080430; CN 1671649 A 20050921; EP 1487782 A1 20041222; IL 166087 D0 20060115

INPADOC legal status


2010-09-08 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20100202

2009-12-23 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20091120

2005-03-16 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: YAHALOMI, RONIT

2005-03-16 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: SHAPIRO, EVGENY

2005-03-16 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: DOLITZKY, BEN-ZION

2005-03-16 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: GOZLAN, YIGAEL

2004-12-22 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20040921

2004-12-22 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

2004-12-22 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Countries: AL LT LV MK