EP 1488005 A1 20041222 - HISTONE DEACETYLASE: NOVEL MOLECULAR TARGET OF NEUROTOXICITY
Title (en)
HISTONE DEACETYLASE: NOVEL MOLECULAR TARGET OF NEUROTOXICITY
Title (de)
HISTONDEACETYLASE : NEUES MOLEKULARES ZIEL VON DER NEUROTOXIZITÄT
Title (fr)
HISTONE DEACETYLASE : NOUVELLE CIBLE MOLECULAIRE DE LA NEUROTOXICITE
Publication
Application
Priority
- FR 0300940 W 20030325
- FR 0203792 A 20020326
- US 37211602 P 20020415
Abstract (en)
[origin: WO03080864A1] The invention concerns the field of biology, genetics and medicine. In particular, it concerns novel methods for detecting, characterizing and/or treating neurodegenerative pathologies, in particular amyotrophic lateral sclerosis. The invention also concerns methods for identifying or screening compounds active in said pathologies. The invention further concerns compounds, genes, cells, plasmids or compositions useful for implementing said methods. In particular, the invention concerns the role of histones deacetylases, and particularly histone deacetylase 2, in said pathologies and its use as therapeutic, diagnostic or experimental target.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/7088 (2006.01); A61P 25/00 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); C12Q 1/34 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01)
CPC (source: EP US)
A61K 31/00 (2013.01 - EP US); A61K 31/7088 (2013.01 - EP US); A61P 25/00 (2017.12 - EP); C12Q 1/6883 (2013.01 - EP US); C12Q 2600/156 (2013.01 - EP US)
Citation (search report)
See references of WO 03080864A1
Citation (examination)
- WO 02102323 A2 20021227 - BRISTOL MYERS SQUIBB CO [US], et al
- MCCAMPBELL A. ET AL: "Histone deacetylase inhibitors reduce polyglutamine toxicity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, vol. 98, no. 26, 18 December 2001 (2001-12-18), pages 15179 - 15184, XP002214670
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 03080864 A1 20031002; AU 2003244713 A1 20031008; CA 2480016 A1 20031002; EP 1488005 A1 20041222; JP 2005520557 A 20050714; US 2005009030 A1 20050113
DOCDB simple family (application)
FR 0300940 W 20030325; AU 2003244713 A 20030325; CA 2480016 A 20030325; EP 03738196 A 20030325; JP 2003578588 A 20030325; US 50275404 A 20040910