EP 1490393 A1 20041229 - 11BETA-SUBSTITUTED 19-NOR-17ALPHA-PREGNA-1,3,5(10)-TRIEN-17BETA-OLS WITH A 21,16ALPHA-LACTONE RING
Title (en)
11BETA-SUBSTITUTED 19-NOR-17ALPHA-PREGNA-1,3,5(10)-TRIEN-17BETA-OLS WITH A 21,16ALPHA-LACTONE RING
Title (de)
11BETA-SUBSTITUIERTE 19-NOR-17ALPHA-PREGNA-1,3,5(10)-TRIEN-17BETA-OLE MIT EINEM 21,16ALPHA-LAKTONRING
Title (fr)
19-NOR-17ALPHA-PREGNA-1,3,5(10)-TRIENE-17BETA-OLS SUBSTITUES EN POSITION 11BETA, COMPORTANT UN CYCLE 21,16ALPHA LACTONE
Publication
Application
Priority
- DE 10214179 A 20020327
- EP 0303221 W 20030327
Abstract (en)
[origin: WO03080642A1] The invention relates to novel 19-nor-17 alpha -pregna-1,3,5(10)-trien-17 beta -ols with a 21,16a lactone ring having a long-chain substituent in the 11 beta position of general formula (II), wherein R<11> represents a long-chain alkyl radical, which comprises a nitrogen atom and which can be substituted on the end by a perfluoroalkyl group. These compounds act, in a tissue-selective manner, as pure antiestrogens and, due to these properties, are suited for producing medicaments.
IPC 1-7
IPC 8 full level
A61K 31/585 (2006.01); A61P 5/30 (2006.01); A61P 15/00 (2006.01); A61P 35/00 (2006.01); C07J 1/00 (2006.01); C07J 41/00 (2006.01); C07J 71/00 (2006.01)
CPC (source: EP)
A61P 5/30 (2017.12); A61P 15/00 (2017.12); A61P 35/00 (2017.12); C07J 1/0003 (2013.01); C07J 41/0077 (2013.01)
Citation (search report)
See references of WO 03080642A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 03080642 A1 20031002; AU 2003216894 A1 20031008; DE 10214179 A1 20031016; EP 1490393 A1 20041229; JP 2005528365 A 20050922
DOCDB simple family (application)
EP 0303221 W 20030327; AU 2003216894 A 20030327; DE 10214179 A 20020327; EP 03712105 A 20030327; JP 2003578395 A 20030327